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Completed

NCT Number: NCT00931151

Effects of Dietary Protein on Undesirable Postprandial Events in Overweight Subjects

Dietary protein differing by their amino acid composition could modulate undesirable metabolic and functional responses to a meal rich in saturated fat and sugars. This study aims at examining the specific effects of dairy protein with different cysteine contents on the postprandial undesirables effects elicited by the ingestion of a high fat meal in overweight subjects.

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Key information

Conditions

Overweight Body Weight Nutrition Disorders Nutritional and Metabolic Diseases Overnutrition Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

18 year–50 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

Centre de recherche sur volontaires

Bobigny, 93, France

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • BMI between 25 and 30
  • Waist circumference > 94 cm

Exclusion criteria

  • Allergy to milk protein
  • Abusive drug consumption
  • Smoking
  • Hypertension, diabetes
  • High level of physical activity

Treatment and study plan

Postprandial metabolic and functional measures

Dietary Supplement

After ingestion of a high fat meal containing the different protein sources, the subjects undergo a series of measures of endothelial dysfunction and blood and urine sampling for the assessment of proinflammatory cytokines levels and metabolomics determinations.

Primary outcomes

  1. Endothelial dysfunction

    Time frame: 0-2-4-6 hours (after meal ingestion)

Secondary outcomes

  1. Postprandial inflammation

    Time frame: 0-0.5-1-1.5-2-3-4-6 hours (after meal ingestion)

Sponsors and collaborators

Lead sponsor

Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement

Other

Collaborators

  • National Research Agency, France

Registry information

Important dates

Study start
2009
Primary completion
2009
Study completion
2009
First posted
Jul 2, 2009
Registry last updated
Aug 23, 2011

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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