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Completed

NCT Number: NCT05273710

Effects of Dietary Folate and Phytate Zinc Absorption: Zinc Amino Acid Complexes vs. Zinc-chloride

The purpose of this study is to determine the effects of consuming a small breakfast of juice and toast with added phytate or with taking a folic acid supplement on the absorption of a small amount of zinc that is either bound to amino acids or to chloride or picolinate. The results of this study will provide new information on how components of diet (e.g., phytate, and folic acid) affect the absorption of different forms of dietary zinc (e.g., zinc bound to amino acids, zinc chloride, and zinc picolinate).

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Key information

Conditions

Dietary Zinc Absorption

Age range

19 year–50 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

University of California

Berkeley, California, 94720, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Apparently healthy men (i.e., have no current health issues requiring medications or a specific diet), 19 to 50 years of age, with a body mass index between 18 and 30 kg/m2, and willing to eat only the foods provided by the study for 17 days

Exclusion criteria

  • Those reporting current chronic or acute diseases or HIV diagnosis, food allergies, smoking tobacco or marijuana, alcohol abuse, any contraindication to venipuncture such as bleeding disorders or use of blood thinners; use of illicit drugs; regular consumption of medications, micronutrient supplements, or both. Vegetarians, or those unable to eat meat, are also excluded since the foods for the study contain meat.

Treatment and study plan

Regular toast and juice

Other

Participants consume a single test meal composed of regular whole wheat toast and apple juice, and zinc absorption is measured.

High phytate toast and juice

Other

Participants consume a single test meal composed of high phytate whole wheat toast and apple juice, and zinc absorption is measured.

Regular toast and juice, with folic acid

Other

Participants consume a single test meal composed of regular whole wheat toast and apple juice, with 400 mcg folic acid; and zinc absorption is measured.

Primary outcomes

  1. Fractional zinc absorption

    Time frame: 48 hours

    Oral zinc tracer to tracee ratio in plasma, as a fraction of intravenous zinc tracer to tracee ratio

Sponsors and collaborators

Lead sponsor

University of California, Berkeley

Other

Registry information

Official study title

Comparison of the Effects of Dietary Folate and Phytate on the Absorption of Zinc From Either Zinc-amino Acids (ZnAA) or Zinc-chloride (ZnCl2)

Important dates

Study start
2022
Primary completion
2022
Study completion
2022
First posted
Mar 10, 2022
Registry last updated
Dec 21, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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