Effects of CUrcuminoids on Coronary Artery byPass graftIng-related myocarDial Infarction Study

It is well-established that myocardial infarction (MI) associated with coronary artery bypass graft surgery (CABG) predicts the poor outcome. Nevertheless, the cardioprotective therapies to limit myocardial injury after CABG are lacking. Previous studies have shown that curcuminoids suppress pro-inflammatory cytokines during cardiopulmonary bypass surgery and decrease the occurrence of cardiomyocytic apoptosis after cardiac ischemia/reperfusion injury in animal models. The investigators aim to evaluate whether curcuminoids prevent MI after CABG, compared to placebo.

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Key information

Conditions

Coronary Artery Bypass Grafting Cardiovascular Diseases Heart Diseases Infarction Ischemia Myocardial Infarction Myocardial Ischemia Necrosis Pathologic Processes Pathological Conditions, Signs and Symptoms Vascular Diseases

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Maharaj Nakorn Chiang Mai hospital

Chiang Mai, 50210, Thailand

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients undergoing CABG without valve surgery

Exclusion criteria

emergency cardiac surgery
any increase in CK-MB above upper limit of normal range (ULN) at the time of randomization
patients with cholestatic jaundice (total bilirubin > 2-fold ULN)
severe liver disease (AST or ALT > 3-fold ULN)

Treatment and study plan

Curcuminoids

Dietary Supplement

Curcuminoids in capsule form, 4 capsules four times daily (4 grams/day)

Placebo

Other

Placebo in capsule form, 4 capsules 4 times/day

Primary outcomes

Incidence of postoperative myocardial infarction

Time frame: participants will be followed for the duration of hospital stay, an expected average of 10 days

Sponsors and collaborators

Lead sponsor

Wanwarang Wongcharoen, MD.

Other

Registry information

Official study title

The Effects of CUrcuminoids on Coronary Artery byPass graftIng-related myocarDial Infarction Study

Acronym: CUPID

Important dates

Study start: 2009
Primary completion: 2011
Study completion: 2012
First posted: Feb 8, 2012
Registry last updated: Sep 18, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

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