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NCT Number: NCT07712653

Effects of Creatine and Carbohydrate Supplementation on Endurance Performance

This study will examine the independent and combined effects of creatine and carbohydrate supplementation on exercise performance, compared to placebo.

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Key information

Conditions

Exercise Performance Recovery

Age range

18 year–40 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

California Polytechnic State University

San Luis Obispo, California, 93407, United States

Location contact

Todd Hagobian, PhD

CONTACT

[email protected]

805-756-7511

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • healthy (i.e. no known cardiovascular disease)
  • nonsmoking
  • active (regular physical activity ≥150 minutes per week of aerobic exercise and have a VO2 peak ≥35 ml/kg-min)
  • a normal BMI (18.5 - 35 kg/m^2)
  • between ages 18-40 years old

Exclusion criteria

  • previously taken creatine and/or any other dietary supplement that may interfere with exercise performance

Treatment and study plan

Creatine Monohydrate

Dietary Supplement

Creatine monohydrate supplementation 0.5 grams every 20 minutes

Carbohydrate

Dietary Supplement

carbohydrate supplementation 5 grams every 20 minutes

Creatine Monohydrate and Carbohydrate

Dietary Supplement

Creatine supplementation of 0.5 grams and carbohydrate supplementation of 5 grams every 20 minutes.

placebo solution

Dietary Supplement

Flavored water every 20 minutes

Primary outcomes

  1. Exercise Time to exhaustion

    Time frame: Change in exercise time to exhaustion ( in seconds) through study completion, over the course of study completion, on average 4 weeks.

    Time to exhaustion (seconds) during continuous cycling performed at 60% of each participant's maximal cycling power output following supplementation with placebo, creatine monohydrate, or creatine monohydrate plus carbohydrate.

Study contacts

Contact information is provided by the study sponsor or research team.

Todd Hagobian, PhD

CONTACT

[email protected]

805-756-7511

Sponsors and collaborators

Lead sponsor

California Polytechnic State University-San Luis Obispo

Other

Registry information

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Jul 17, 2026
Registry last updated
Jul 21, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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