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NCT Number: NCT07344727

Impact of Haskap Berries on Recovery From High Intensity Resistance Training

The purpose of this clinical trial is to determine how certain food items affect oxidative stress, inflammation, and performance recovery from exercise induced muscle damage in a resistance trained population. The main questions The investigators aim to answer are the following:

* Do Haskaps speed the recovery of oxidative stress and inflammation markers after an intense lower body workout in resistance trained adults? * Do Haskaps speed the recovery of performance measures after an intense lower body workout in resistance trained adults? * The data collected in this investigation may also be used to ask additional questions not yet identified. For example, the investigators may use the stored samples to evaluate how the blood metabolites of participants differ before and after intense exercise. These additional questions are called secondary analyses. Please note that no genetic analysis will be conducted and racial and ethnic differences among participants will not be used in any secondary analyses.

Researches will compare Haskap juice to a color, flavor and carbohydrate matched placebo to see if Haskaps speed recovery in inflammation, oxidative stress and performance.

* Participants will be asked to drink either Haskap juice or placebo and follow a low polyphenolic diet * Participants will perform an intense resistance workout * Participants will have their blood drawn before and after the workout * Performance will be analyzed at 24, 48 and 72 hours after the workout

Recruiting

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Key information

Age range

18 year–35 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

About this study

The main goal of the clinical trial is to learn more about how the haskap berry impacts the recovery process form intense resistance training. Haskap berries are very high in several compounds that function as antioxidants, such as polyphenols and vitamin C, which have many health promoting effects. For example, antioxidants lower inflammation and oxidative stress, which is known to cause damage to cells, proteins, and DNA. Oxidative stress is a result of excess free radicals, which are unstable molecules that can be created, along with inflammation, during intense exercise. This combination of excessive harmful byproducts in the body can cause soreness and decrease muscle performance experienced after a workout. However, the antioxidants in foods have the ability to neutralize free radicals that are produced and may reduce the time to recover from exercise.

To do this, a parallel, randomized, double blind, placebo controlled clinical trial of Haskap versus a placebo on resistance trained individuals will be completed. Participants will complete an intense workout consisting of barbell back squats and leg extension. Participants will drink either Haskap juice or placebo and follow a low polyphenolic diet for a total of 11 days. Participants will have their blood drawn before supplementation, before, immediately after and 8, 24, 48, and 72 hours after the workout to track recovery of blood markers. Performance will be analyzed via vertical jumps on force plates, maximal voluntary contraction of the quadriceps on a biodex, and speed of the squat at 24, 48, and 72 hours post workout.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • 2+ years of barbell squat experience
  • Currently squatting at least once a week

Exclusion criteria

  • BMI <18 or > 40 kg/m^2
  • potential allergy to Haskap or placebo ingredients
  • anti-inflammatory, weight loss, anabolic steroids, testosterone, or other drugs that may interfere with the measures of the study or any other medications that may interfere with study measures
  • pregnant or lactating woman
  • diagnosis with type 1 or type 2 diabetes, hypo-/hyperthyroidism or any other condition that may interfere with study measures
  • smoke cigarettes
  • lower extremity injury within the last year
  • currently following a special diet including vegan, vegetarian, low carbohydrate, or ketogenic.
  • currently consuming any of the following products: tart cherry juice, pomegranate juice, or 1 or more cups of acai or other berries per day.

Treatment and study plan

Haskap berry smoothie

Dietary Supplement

A smoothie blend of berries and water

Placebo Comparator

Dietary Supplement

A smoothie with no polyphenolic content and matched in carbohydrate composition to the experimental haskap smoothie

Primary outcomes

  1. Force Production

    Time frame: 72 hours

    Maximal Voluntary Contraction (MVC) to assess force production of knee extensors at 60 degrees.

  2. Barbell Velocity

    Time frame: 72 hours

    Barbell velocity will be measure to determine how squat velocity recovers over the course of the study.

  3. Vertical Jump

    Time frame: 72 hours

    Force plates will be used to evaluate vertical jump height.

  4. Inflammation (pg/mL)

    Time frame: 11 days

    Serum interleukin (IL) IL-6, IL-10, IL-1ra, tumor necrosis factor alpha (TNF-alpha),

  5. Lipid peroxidation

    Time frame: 11 days

    Plasma Malondialdehyde (MDA)

  6. Creatine Kinase

    Time frame: 11 days

    Plasma

  7. C-Reactive Protein

    Time frame: 11 days

    Plasma

  8. Protein Carbonyls

    Time frame: 11 days

    Plasma

Secondary outcomes

  1. Soreness

    Time frame: 72 hours

    Soreness will be evaluated objectively by participants drawing a line on a scale of 0-10 of how sore their legs are. 0 represents no soreness at all and 10 represents the most muscular soreness the participant has felt. A lower number could indicate less inflammation and muscular damage.

  2. Acute Diet

    Time frame: 9 days

    24-hour dietary recall using the Automated Self-Administered 24-hour Dietary. Assessment Tool (ASA24). Outcome is macronutrient and micronutrient composition of food entry.

  3. Sleep Questionnaire

    Time frame: 11 days

    Participants report information on the previous night's sleep. What time they went to sleep, how long it took them to fall asleep, how many hours they slept, whether these were normal sleep and wake times and how restful they perceive their sleep to be on a scale of 1 to 10. 1 indicates their sleep was not restful at all and 10 indicates their sleep was as restful as possible.

Study contacts

Contact information is provided by the study sponsor or research team.

Adrianna Yeats

CONTACT

[email protected]

3864516656

Bryce Peterson

CONTACT

[email protected]

40666975460

Sponsors and collaborators

Lead sponsor

Montana State University

Other

Collaborators

  • Montana State Agricultural Experiment Station

Registry information

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Jan 15, 2026
Registry last updated
Jan 21, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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