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Completed

NCT Number: NCT03860441

Effects of Cognitive Intervention on Cognition, Mobility and Brain Electrocortical Activity

Within this project the investigators tested the effectiveness of 2-month of computerized cognitive training (CCT) on CogniFit online platform on 77 older adults, which were randomly divided into intervention and control group. The investigators tested close (battery of cognitive functions) and far transfer (postural and mobility control, EEG, blood samples) of the CCT. Additionally, the investigators were interested into seeing a long-lasting effect, therefore participants were brought back to the laboratory 1 year post CCT.

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Key information

Conditions

Cognitive Decline Aging Cognition Disorders Cognitive Dysfunction Cognitive Impairment Mental Disorders Motor Coordination or Function Neurocognitive Disorders

Age range

60 year–90 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Center for Daily Activity Koper (Slovenia)

Koper, 6000, Slovenia

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • active and healthy older adults with no major health issues
  • members of the Center for Daily Activity Koper (Slovenia)
  • had normal or corrected-to-normal vision;
  • reported no history of cardiovascular, neurological, or psychiatric conditions

Exclusion criteria

  • younger than 60
  • smoking; regular alcohol consumption;
  • acute or chronic skeletal, neuromuscular, metabolic and cardiovascular disease condition;

Treatment and study plan

Computerized cognitive training

Other

Intervention used CogniFit platform with Personalized brain training sub-option

Other names: cognitive remediation, cognitive training

Primary outcomes

  1. Change in gait speed

    Time frame: up to 8 weeks

    The primary outcome is change in gait speed during single- and dual-task conditions from baseline to post-intervention.

Secondary outcomes

  1. Executive control (Trail-Making Task Forms A and B)

    Time frame: up to 8 weeks

    Secondary outcome is change in executive control, measured with TMT A and B tests

  2. Sensorimotor integration measured with EEG/ERP methodology

    Time frame: up to 8 weeks

    Secondary outcome is change ERP components P1, N1, P2 and P3 (amplitudes and latencies)

  3. Brain-derived neurotrophic factor (BDNF) extracted from peripheral blood sampling

    Time frame: up to 8 weeks

    Secondary outcome is change in plasma BDNF plasma extraction evaluated in pg/mL

Sponsors and collaborators

Lead sponsor

Science and Research Centre Koper

Other

Collaborators

  • Albert Einstein College of Medicine
  • University of Primorska
  • Vrije Universiteit Brussel

Registry information

Official study title

Holistic Approach for Active and Healthy Aging: Physical and Cognitive Activity, and Nutrition

Acronym: GIBKOP

Important dates

Study start
2017
Primary completion
2018
Study completion
2018
First posted
Mar 4, 2019
Registry last updated
Mar 5, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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