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NCT Number: NCT06239922

Cognitive and Neural Assessment Platform and Localized Norm for Macau Older Adults.

The current project is dedicated to creating a comprehensive cognitive and neural assessment platform and corresponding norms tailored specifically to the older adults in Macau.

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Key information

Conditions

Cognition Disorders in Old Age Aging Cognition Disorders Cognitive Change Cognitive Decline Cognitive Dysfunction Cognitive Impairment Mental Disorders Neurocognitive Disorders

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Centre for Cognitive and Brain Sciences of the University of Macau

Macao, Macao SAR, 999078, Macau

Location contact

Haoyun ZHANG Assistant Professor

CONTACT

[email protected]

+853 88229212

Haoyun ZHANG Assistant Professor, Ph.D

PRINCIPAL_INVESTIGATOR

LEI KEI KEI Research Assistant, MSc

CONTACT

[email protected]

+853 8822 9198

About this study

The investigators will establish this assessment platform using a combination of methods, including interviews, surveys, and expert reviews.

Steps include adapting existing assessment methods to the Macau context, developing new cognitive and neural tasks, defining standardized procedures, seeking external expert input, conducting pilot tests, and validation processes, and refining both the platform and its accompanying manual.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Must be a local adult resident of Macau
  • Age above 50 years for older adult cohort
  • Younger adults individuals above 18 will be included as control comparators

Exclusion criteria

  • History of neurological injury or disease
  • Current use of medications that affect brain function or blood flow
  • Contraindications to MRI scanning, such as the presence of an electric/mechanical implant or device (e.g., pacemaker)
  • Claustrophobia
  • Body weight over 300 lbs due to weight and physical constraints of the scanner (i.e., bore size limited to 55 cm)
  • Inability to provide informed consent
  • Pregnancy
  • Being under the legal age of adulthood (children)
  • Incarcerated individuals (prisoners)

Treatment and study plan

Primary outcomes

  1. Normative Data for the Montreal Cognitive Assessment - Chinese (Hong Kong) version

    Time frame: From February 2024 to January 2026

    The MoCA will be administered to derive a normative data set representative of the older adult population in Macau.

  2. Normative Data for the Mini-Mental State Examination (MMSE)

    Time frame: From February 2024 to January 2026

    The MMSE will be administered to derive a normative data set representative of the older adult population in Macau.

  3. Normative Scores for Computerized Neuropsychological Tasks

    Time frame: From February 2024 to January 2026

    Neuropsychological tasks will be employed to measure selective attention capacity and processing speed in the study cohort. These tasks will provide quantifiable data on the efficiency and accuracy of cognitive processing. The collective performance on these tasks will be used to establish benchmark values - including means, medians, and ranges - that define the normative standards for these cognitive abilities in the population.

Secondary outcomes

  1. Neural Activation Patterns During Cognitive Tasks as Revealed by Functional Magnetic Resonance Imaging (fMRI)

    Time frame: From February 2024 to January 2026

    fMRI data will be collected to identify patterns of neural activation associated with cognitive task performance.

  2. Cerebral Hemodynamics Assessed Through Functional Near-Infrared Spectroscopy (fNIRS)

    Time frame: From February 2024 to January 2026

    fNIRS will be employed to measure cerebral blood flow and oxygenation during cognitive tasks.

  3. Electrophysiological Correlates of Cognitive Activity as Measured by Electroencephalography (EEG)

    Time frame: From February 2024 to January 2026

    EEG will be utilized to record the electrical activity of the brain during cognitive tasks. Key outcome metrics will include event-related potentials (ERPs) amplitudes and latencies, with mean values and variability measures reported for the cohort.

Study contacts

Contact information is provided by the study sponsor or research team.

Haoyun ZHANG Assistant Professor

CONTACT

[email protected]

+853 88229212

LEI KEI KEI research assistant, MSc

CONTACT

[email protected]

+853 88229198

Sponsors and collaborators

Lead sponsor

University of Macau

Other

Registry information

Official study title

Establishing Cognitive and Neural Assessment Platform and Localized Norm for Macau Older Adults

Important dates

Study start
2024
Primary completion
2026
Study completion
2026
First posted
Feb 2, 2024
Registry last updated
Feb 2, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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