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OpenTrials
Completed

NCT Number: NCT03817944

Effects of Coffee Consumption on Health Among Adults

The purpose of this study is to research the changes of typical thermal processing food intervention on health outcome, metabolites, and gut microbiota, in order to explore the molecular mechanism of interaction between maillard reaction associated hazards and complex food matrix, and provide scientific basis and reference model for combining food nutrition and safety protection.

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Key information

Conditions

Health Body Weight Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

17 year–29 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Zhejiang university

Hangzhou, China

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Non-smoking, non-occupational exposed healthy volunteers, 18.5<BMI<30 kg/m^2, were screened. If the evaluation of disease history, blood biochemistry and blood routine was normal, the volunteers were considered healthy.

Exclusion criteria

  • The main exclusion criteria included people with high exposure to cold and fever, recent drug intake (including dietary supplement intake), alcohol intake, vegetarians, pregnancy, high-temperature processed meat and beverages such as coffee and milk tea.

Treatment and study plan

Warm water

Other

300 mL Warm Water per day for 8 weeks

Caffeinated coffee

Other

300 mL Caffeinated Coffee per day for 8 weeks

Decaffeinated coffee

Other

300 mL Decaffeinated Coffee per day for 8 weeks

Primary outcomes

  1. Change in blood glucose from baseline

    Time frame: 8 weeks

  2. Change in blood lipids from baseline

    Time frame: 8 weeks

Secondary outcomes

  1. Urinary biomarkers levels of acrylamide, furans, and furfuryl alcohol

    Time frame: 8 weeks; 24 hours

    Urinary levels of environmental pollutants (e.g., acrylamide, furans, and furfuryl alcohol), measured using liquid chromatography-mass spectrometry (LC-MS)

  2. Change of metabolites

    Time frame: 8 weeks

  3. Change in gut microbiota

    Time frame: 8 weeks

Sponsors and collaborators

Lead sponsor

Zhejiang University

Other

Registry information

Official study title

Placebo-controlled Study on Intervention Effect of Coffee on Glucose and Lipid Homeostasis Disorders

Important dates

Study start
2021
Primary completion
2021
Study completion
2021
First posted
Jan 28, 2019
Registry last updated
May 6, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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