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NCT Number: NCT02196870

Effects of Chest Wall Elastance on Pulmonary Mechanics of Acute Respiratory Failure (ARF)

Patients with chest wall elastance increasing could worsen lung function. Increasing of chest wall elastance plays a great role in lung mechanics, and could influence mechanical ventilation settings. Therefore, It could help the physicians to find appropriate indicators and optimize the treatments of ARF patients to explore the mechanisms of lung mechanics changse in the patients with high chest wall elastance.

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Key information

Conditions

Airway Pressure Stress Index Acute Respiratory Failure Chest Wall Elastance Transpulmonary Pressure Stress Index

Age range

18 year–85 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Zhongda Hospital

Nanjing, Jiangsu, 210009, China

About this study

Mechanical ventilation(MV) is an important treatment for acute respiratory failure(ARF) patients, could improve hypoxemia, maintain lung volume and promote alveolar opening. However, because of barotrauma, volutrauma and biotrauma, MV could cause or aggravate acute lung injury not only in acute respiratory distress syndrome(ARDS) patients, but in patients with normal lung function1,2.

Patients with chest wall elastance increasing could worsen lung function. Increasing of chest wall elastance plays a great role in lung mechanics, and could influence mechanical ventilation settings. Therefore, It could help the physicians to find appropriate indicators and optimize the treatments of ARF patients to explore the mechanisms of lung mechanics changse in the patients with high chest wall elastance.

The present study is set out to examine the effects of high chest wall elastance on changes of lung mechanics and the correlation of airway pressure(Paw) stress index and transpulmonary pressure(PL) stress index.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • ARF
  • mechanical ventilation
  • cardiovascular stable

Exclusion criteria

  • age < 18y or > 85y
  • pregnancy
  • COPD or chronic pulmonary disease

Treatment and study plan

Primary outcomes

  1. Changes of oxygenation and lung mechanics

    Time frame: up to 24 months

Sponsors and collaborators

Lead sponsor

Southeast University, China

Other

Registry information

Official study title

Physiological Effects of Chest Wall Elastance on Pulmonary Mechanics of Acute Respiratory Failure Patientstranspulmonary Pressure

Important dates

Study start
2014
Primary completion
2015
Study completion
2015
First posted
Jul 22, 2014
Registry last updated
Jun 24, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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