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Completed

NCT Number: NCT07155915

Effects of Cherry Consumption on Metabolic Health

This study is designed to evaluate the effects of daily sweet cherry consumption on markers of metabolic health in adults. Cherries are rich in bioactive compounds, such as anthocyanins and phenolic acids, which may help reduce oxidative stress, inflammation, and early risk factors for conditions like type 2 diabetes and cardiovascular disease. Participants will consume 280 grams of fresh sweet cherries every day for 42 consecutive days. Blood and urine samples will be collected at four time points: before the intervention (baseline), at day 21, at day 42 (end of the intervention), and two weeks after stopping cherry consumption.

The study will measure changes in blood sugar regulation, markers of inflammation, oxidative stress, liver and kidney function, and immune response. Waist circumference and body mass index will also be recorded.

The aim of this study is to test whether daily cherry consumption can support metabolic health in healthy adults and to provide data that may inform larger and longer clinical trials in the future.

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Key information

Conditions

Metabolic Health

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Instituto Politécnico da Guarda

Guarda, Portugal

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age 18-65 years old
  • Healthy individuals with no known metaboli disorders

Exclusion criteria

  • Alcohol consumption
  • Smoking
  • Adverse or allergic reaction to cherries
  • Use of antibiotics, anxiolytics, or dietary supplements
  • Pregnancy or lactation
  • Weight changes greater than 10% in the previous year.

Treatment and study plan

Sweet cherries, 280 g daily for 42 days

Dietary Supplement

Participants will consume 280 grams of fresh sweet cherries daily for 42 consecutive days. Cherries are provided in pre-weighed portions to be consumed in the morning on an empty stomach

Primary outcomes

  1. Changes in fasting glucose

    Time frame: Baseline, Day 21, Day 42 and 2 weeks post-intervention

  2. Changes in HbA1c

    Time frame: Baseline, Day 21, Day 42 and 2 weeks post-intervention

  3. Changes in estimated average glucose

    Time frame: Baseline, Day 21, Day 42 and 2 weeks post-intervention

  4. Changes in insulin

    Time frame: Baseline, Day 21, Day 42 and 2 weeks post-intervention

  5. Changes in IL-6

    Time frame: Baseline, Day 21, Day 42 and 2 weeks post-intervention

  6. Changes in AGP-1

    Time frame: Baseline, Day 21, Day 42 and 2 weeks post-intervention

  7. Changes in C-reactive protein

    Time frame: Baseline, Day 21, Day 42 and 2 weeks post-intervention

  8. Changes in gluthatione peroxidase

    Time frame: Baseline, Day 21, Day 42 and 2 weeks post-intervention

  9. Changes in gluthatione reductase

    Time frame: Baseline, Day 21, Day 42 and 2 weeks post-intervention

  10. Changes in glutamate dehydrogenase

    Time frame: Baseline, Day 21, Day 42 and 2 weeks post-intervention

Secondary outcomes

  1. Changes in aspartate aminotransferase

    Time frame: Baseline, Day 21, Day 42 and 2 weeks post-intervention

  2. Changes in alanine transaminase

    Time frame: Baseline, Day 21, Day 42 and 2 weeks post-intervention

  3. Changes in gamma-glutamyl transferase

    Time frame: Baseline, Day 21, Day 42 and 2 weeks post-intervention

  4. Changes in total bilirubin

    Time frame: Baseline, Day 21, Day 42 and 2 weeks post-intervention

  5. Changes in conjugated bilirubin

    Time frame: Baseline, Day 21, Day 42 and 2 weeks post-intervention

  6. Changes in unconjugated bilirubin

    Time frame: Baseline, Day 21, Day 42 and 2 weeks post-intervention

  7. Changes in lactate dehydrogenase

    Time frame: Baseline, Day 21, Day 42 and 2 weeks post-intervention

  8. Changes in total proteins

    Time frame: Baseline, Day 21, Day 42 and 2 weeks post-intervention

  9. Changes in albumin

    Time frame: Baseline, Day 21, Day 42 and 2 weeks post-intervention

  10. Changes in urea

    Time frame: Baseline, Day 21, Day 42 and 2 weeks post-intervention

  11. Changes in creatinine

    Time frame: Baseline, Day 21, Day 42 and 2 weeks post-intervention

  12. Changes in microalbumin

    Time frame: Baseline, Day 21, Day 42 and 2 weeks post-intervention

  13. Changes in uric acid

    Time frame: Baseline, Day 21, Day 42 and 2 weeks post-intervention

  14. Changes in iron

    Time frame: Baseline, Day 21, Day 42 and 2 weeks post-intervention

  15. Changes in TIBC

    Time frame: Baseline, Day 21, Day 42 and 2 weeks post-intervention

  16. Changes in transferrin

    Time frame: Baseline, Day 21, Day 42 and 2 weeks post-intervention

  17. Changes in ferritin

    Time frame: Baseline, Day 21, Day 42 and 2 weeks post-intervention

  18. Changes in amylase

    Time frame: Baseline, Day 21, Day 42 and 2 weeks post-intervention

  19. Changes in lipase

    Time frame: Baseline, Day 21, Day 42 and 2 weeks post-intervention

  20. Changes in IgA

    Time frame: Baseline, Day 21, Day 42 and 2 weeks post-intervention

  21. Changes in IgG

    Time frame: Baseline, Day 21, Day 42 and 2 weeks post-intervention

  22. Changes in IgM

    Time frame: Baseline, Day 21, Day 42 and 2 weeks post-intervention

  23. Changes in total IgE

    Time frame: Baseline, Day 21, Day 42 and 2 weeks post-intervention

  24. Changes in rheumatoid factor

    Time frame: Baseline, Day 21, Day 42 and 2 weeks post-intervention

  25. Changes in antistreptolysin O

    Time frame: Baseline, Day 21, Day 42 and 2 weeks post-intervention

  26. Changes in triglycerides

    Time frame: Baseline, Day 21, Day 42 and 2 weeks post-intervention

  27. Changes in total cholesterol

    Time frame: Baseline, Day 21, Day 42 and 2 weeks post-intervention

  28. Changes in HDL cholesterol

    Time frame: Baseline, Day 21, Day 42 and 2 weeks post-intervention

  29. Changes in LDL cholesterol

    Time frame: Baseline, Day 21, Day 42 and 2 weeks post-intervention

  30. Changes in waist circumference

    Time frame: Baseline and Day 42

  31. Body Mass Index

    Time frame: Baseline and Day 42

Sponsors and collaborators

Lead sponsor

Instituto Politécnico da Guarda

Other

Registry information

Official study title

Effects of Cherry Consumption on Metabolic Health: A Pilot Clinical Study on Healthy Adults

Important dates

Study start
2024
Primary completion
2024
Study completion
2024
First posted
Sep 4, 2025
Registry last updated
Sep 4, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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