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NCT Number: NCT06250270

Effects of Casein Protein on Metabolism When Taken Prior to Sleep and in the Morning

The purpose of this study is to investigate the effect of casein protein consumption both prior to sleep as well first thing in the morning on metabolism (increase satiety and appetite, lower resting metabolic rate, and lower blood sugar levels), when compared to nighttime protein or placebo consumption alone. Protein itself is a macronutrient that not only helps the body repair itself, and play a critical role in growth, it also aids in increasing satiety and decreasing appetite. Casein protein specifically is slow digesting dairy protein which may impact the body's metabolism for a longer period than other dairy proteins such as whey. The literature demonstrates nighttime protein ingestion prior to sleep increases metabolic rate and satiety the next morning. However, there appears to be no data on the metabolic effects of protein ingested both at night and in the morning.

Active, Not Recruiting

This study is active but is not currently recruiting participants.

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Key information

Conditions

Metabolism

Age range

18 year–30 year

Sex eligibility

Male

Study type

Interventional

Phase

Early Phase 1

Primary location

Ohio University Exercise Physiology Lab

Athens, Ohio, 45701, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • male
  • aged 18-30

Exclusion criteria

  • lactose intolerant
  • having known sleep issues
  • being on a schedule that is not uniform week to week
  • those who do not eat animal-based diets
  • any known or suspected food allergies
  • any known health conditions (cardiovascular disease, IBS, high blood pressure, diabetes, crohn's disease)
  • those that have disordered eating
  • unwillingness to take blood sugar four times a day
  • being a female

Treatment and study plan

protein or placebo

Dietary Supplement

casein protein (30g) or placebo (maltodextrin, 30g)

Primary outcomes

  1. resting metabolic rate

    Time frame: baseline, during the intervention

    indirect calorimetry to measure oxygen consumption (V02) and respiratory quotient (RQ)

  2. blood glucose

    Time frame: baseline, during the intervention

    fasting and pre-meal blood glucose

Secondary outcomes

  1. dietary intake

    Time frame: during the intervention

    food logs used to track food intake during all trial visits

Sponsors and collaborators

Lead sponsor

Ohio University

Other

Registry information

Important dates

Study start
2022
Primary completion
2024
Study completion
2025
First posted
Feb 9, 2024
Registry last updated
Jul 30, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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