Skip to main content
OpenTrials
Completed

NCT Number: NCT05995314

Effects Of Caffeine On Cognitive Performance

Caffeine is a potent central nervous system stimulant that increases the activity in the prefrontal cortex and can improve cognitive skills. An improvement in these cognitive skills can lead to further benefits in athletic performance. Therefore, it is necessary to clarify the dose-response of caffeine on cognitive performance.The aim of this research will be to determine the effects of different doses of caffeine on sport-related cognitive aspects.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Caffeine

Age range

18 year–30 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Performance and Sport Rehabilitation Laboratory

Toledo, 45071, Spain

About this study

The investigators will require healthy, physically active young adults to complete three trials under the conditions: a) placebo, b) 3 mg/kg, or c) 6 mg/kg body mass of caffeine. In each trial, different cognitive abilities will be assessed using the following test batteries: reaction time (DynavisionTM D2), anticipation (Bassin Anticipation Timer), sustained attention (Go/No-Go and Eriksen Flanker Test) and memory tests. In addition, side effects and the perceived sensation index will be recorded 24 h after each test.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Physically active individuals ( >150 min/week moderate physical activity or >75 min/week vigorous physical activity)
  • Individuals without serious and undiagnosed health problems.

Exclusion criteria

  • Individuals with color blindness.
  • Regular caffeine consumers (>3 cups of coffee/day).

Treatment and study plan

Placebo

Dietary Supplement

3 mg/kg of cellulose (0 mg/kg of caffeine)

3 mg/kg of caffeine

Dietary Supplement

Ingestion of 3 mg/kg of body mass of caffeine

6 mg/kg of caffeine

Dietary Supplement

Ingestion of 6 mg/kg of body mass of caffeine

Primary outcomes

  1. Reaction Time

    Time frame: 10 minutes

    Reaction time (in seconds) shall be assessed with the Dynavision™ D2 Visomotor Device using the "Reaction Time Test". In this test the fastest visual, motor and physical reaction time will be measured.

  2. Anticipation

    Time frame: 5 minutes

    Visual acuity related to hand-eye coordination and anticipation will be assessed using the Bassin Anticipation Timer instrument. The best anticipation time (in seconds) of each condition (5, 10 and 15 mph) will be taken.

  3. Sustained attention

    Time frame: 10 minutes

    The ability of maintaining the attention and inhibiting an appropriate response will be measured by "Go/No-Go Test" [fastest, slowest, and average response time (in seconds), and successful attempts (percentage; %)] and "Eriksen Flanker Test" [congruent and incongruent reaction time (in seconds)].

  4. Memory

    Time frame: 20 minutes

    To study the modulation of memory storage processes, three 20-item word lists were created. Each word in the list will be presented for 5 s. This will be followed by a 100 s memory consolidation interval, after which there will be a 120 s period in which as many words as the participants can remember will be written down (First time). After 15 min, participants will perform a recall task (Second time) in which they will have to rewrite all the words they remember at that time.

Sponsors and collaborators

Lead sponsor

University of Castilla-La Mancha

Other

Registry information

Official study title

Effects Of Different Doses Of Caffeine On Cognitive Performance In Healthy Physically Active Individuals

Important dates

Study start
2023
Primary completion
2023
Study completion
2023
First posted
Aug 16, 2023
Registry last updated
Sep 6, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.