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Completed

NCT Number: NCT07711652

Acute Caffeine Intake in Young vs Older Adults

Evidence regarding the ergogenic effects of caffeine is well-established in young adults, but evidence in older adults remains scarce, particularly during dynamic resistance exercise. Therefore, this study compared the effects of acute caffeine ingestion on upper- and lower-body muscular strength and endurance performance according to age, in young and older adults.

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Key information

Conditions

Caffeine Placebo

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Facultad de Medicina y Ciencias de la Salud. Universidad de Alcalá

Alcalá de Henares, Madrid, 28805, Spain

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age between ≥18 and 35 years in young adults and ≥ 55 and 80 years in older adults.
  • Body mass index (BMI) lower than 25 kg/m².
  • Physically active subjects (≥150 min/week of moderate exercise).
  • Healthy men and women without neurological, cardiometabolic, immunological, or physical conditions that prevent them from performing physical exercise.
  • Participants capable of performing the tests.

Exclusion criteria

  • History of neuromuscular, cardiac, or diseases that could affect liver or muscle metabolism.
  • Use of drugs or other stimulants that interfere with caffeine intake and intestinal absorption during the tests and study.
  • Body mass index (BMI) ≥ 25 kg/m².
  • Having undergone prolonged periods of forced physical inactivity during the 6 months prior to the study.
  • Performing strenuous exercise within 48 hours prior to the tests.• Failing to replicate the same food intake on the two experimental days.
  • Consuming caffeine after 6 PM on the day prior to training or testing.

Treatment and study plan

Caffeine

Dietary Supplement

Acute caffeine intake (3 mg/kg)

Placebo

Dietary Supplement

(3 mg/kg maltodextrin)

Primary outcomes

  1. Mean velocity at different %1RM

    Time frame: Through study completion, an average of 3 weeks

    Mean velocity at different %1RM (25-90%1RM)

  2. Number of repetitions performed in 1 set at 65%1RM until task failure

    Time frame: Through study completion, an average of 3 weeks

    In bench press and back squat exercises

  3. Bar velocity displacement performed in 1 set at 65%1RM until task failure

    Time frame: Through study completion, an average of 3 weeks

    In bench press and back squat exercises

  4. handgrip and isometric mid-thigh pull tests

    Time frame: Through study completion, an average of 3 week

    N generated

Secondary outcomes

  1. cyp1a2 polymorphism

    Time frame: Before the beginning of the trial

    Using saliva sample and PCR

  2. Mood state (tension, depression, anger, vigor, fatigue and confusion)

    Time frame: Through study completion, an average of 3 weeks

    Participants graded a set of 29 items related to the mood on a Likert scale from 0 (not at all) to 4 (extremely) in reply to the question: How do you feel at this moment? to assess six scales: tension, depression, anger, vigor, fatigue and confusion.

  3. Adverse effects

    Time frame: Through study completion, an average of 3 weeks

    perception of power, endurance, energy and exertion, as well as heart, muscular and gastrointestinal discomfort

Sponsors and collaborators

Lead sponsor

University of Alcala

Other

Registry information

Official study title

Effect of Acute Caffeine Intake According to Age

Acronym: CAF+Age

Important dates

Study start
2023
Primary completion
2025
Study completion
2026
First posted
Jul 17, 2026
Registry last updated
Jul 17, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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