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Completed

NCT Number: NCT05911490

Effects of Breaking Sitting on Human Behaviour and Metabolic Health

This study primarily aimed to investigate effects of breaking up prolonged sitting with intermittent brisk walking in healthy young individuals on (1) post-trial human behaviours including energy intake and physical activity under free-living conditions and (2) cognitive performance in a simulated workplace environment.

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Key information

Conditions

Energy Balance Behavior Behavior, Animal Cognition Feeding Behavior Metabolic Health Physical Activity Level

Age range

20 year–45 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

National Taiwan Normal University

Taipei, Taiwan

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Without current and any history of brain injury, neurological disorder, cardiometabolic related diseases, diabetes or cancers.
  • Weight stable (not self-reported weight change ± 3 kg at least 3 months)
  • Body mass index (BMI) ranging between 18.5 to 27 kg/m2
  • Can walk safely on a treadmill

Exclusion criteria

  • Smokers, post-menopausal female, and volunteers who used any medications that could influence metabolic and inflammatory responses.

Treatment and study plan

Prolonged sitting

Behavioral

In the laboratory, after consuming 1st meal, participants sat on a chair for 180 min. After 180 min, the 2nd meal was provided. After finishing the 2nd meal, participants sat on a chair for another 120 min. After data collection was completed in the laboratory, participants were asked to keep wearing the same pedometer and to record any food and liquid consumption for the rest of the day (until midnight) under free-living conditions.

Breaking prolonged sitting

Behavioral

In the laboratory, after consuming 1st meal, participants walked 2 min on a treadmill every 20 minutes for the following 180 min. For the remainder of the time participants sat on the chair. After 180 min, the 2nd meal was provided. After finishing the 2nd meal, participants continued 2 min of walking every 20 min for the following 120 min. After data collection was completed in the laboratory, participants were asked to keep wearing the same pedometer and to record any food and liquid consumption for the rest of the day (until midnight) under free-living conditions.

Primary outcomes

  1. Physical activity level

    Time frame: 480 minutes

    Changes in physical activity level (steps) in the free-living conditions

  2. Energy intake

    Time frame: 480 minutes

    Changes in energy intake (kcal) in the free-living conditions

  3. Cognitive performance

    Time frame: 320 minutes

    Changes in cognitive performance (% changes in accuracy) including Task Switching and Flanker tasks

  4. Cognitive function

    Time frame: 320 minutes

    Changes in cognitive performance (% changes in reaction time) Task Switching and Flanker tasks

Secondary outcomes

  1. Postprandial glucose concentrations

    Time frame: 320 minutes

    Changes in postprandial finger pricking glucose concentrations

  2. Blood pressure

    Time frame: 320 minutes

    Changes in systolic blood pressure and diastolic blood pressure

  3. Visual analogue scale (VAS)

    Time frame: 320 minutes

    Changes in self-perceived sensations including appetite, energy and mood (score from 0-100)

  4. Continuous glucose monitoring

    Time frame: 320 minutes

    Changes in different depots of adipose tissue interstitial glucose concentrations

Sponsors and collaborators

Lead sponsor

National Taiwan Normal University

Other

Collaborators

  • Division of Endocrinology and Metabolism, Tri-Service General Hospital

Registry information

Official study title

Effects of Breaking Prolonged Sitting on 24-h Human Behaviours, Self-feelings, Metabolic Health and Cognition in Healthy Adults

Important dates

Study start
2019
Primary completion
2020
Study completion
2020
First posted
Jun 22, 2023
Registry last updated
Jun 22, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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