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Completed

NCT Number: NCT06208475

Different Menstrual Cycle in Eating Behavior Following Resistance Exercise

The study aims to provide insights into how menstrual cycle phases impact appetite responses to resistance exercise in young women. Healthy young women will participate in four trials: the exercise session in the follicular phase, the exercise session in the luteal phase, the control session in the follicular phase, and the control session in the luteal phase. Various measurements will be taken, including subjective appetite perceptions, appetite hormones, food preferences, lactate levels, estradiol levels, progesterone levels, and energy intake.

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Key information

Age range

20 year–30 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

National Taiwan Normal University

Taipei, 106, Taiwan

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age: 20-30
  • Healthy female with normal menstruation
  • Weight stable for at least 6 months

Exclusion criteria

  • Overweight (BMI > 30 kg/m^2 or body fat > 30%)
  • Hypertension (> 140/90 mmHg)
  • Cardiovascular disease, cancer or other chronic diseases

Treatment and study plan

Resistance Exercise

Other

Resistance exercises in the following order: squat, bench press, deadlift. Each exercise consisted of 3 sets with 7 repetitions, using a load of 70% 1RM with 120sec of rest between sets.

Primary outcomes

  1. Subjective appetite

    Time frame: 4 hours during each study intervention

    The appetite perceptions are obtained through a 0-100 mm visual analog scale. The variables assessed include perceptions of hunger (i.e., "How hungry do you feel?"), satisfaction (i.e., "How satisfied do you feel?"), fullness (i.e., "How full do you feel?"), prospective food consumption (i.e., "How much do you think you can eat?"), and nausea (i.e., "How nauseous do you feel?"), with 0 indicating "not at all" and 100 signifying "extremely.".

  2. Change in acyl-Ghrelin

    Time frame: 4 hours during each study intervention

    acyl-Ghrelin in pg/mL

  3. Change in total-Ghrelin

    Time frame: 4 hours during each study intervention

    total-Ghrelin in pg/mL

  4. Change in PYY

    Time frame: 4 hours during each study intervention

    PYY in pg/mL

  5. Change in active-GLP-1

    Time frame: 4 hours during each study intervention

    active-GLP-1 in pg/mL

  6. Change in total-GLP-1

    Time frame: 4 hours during each study intervention

    total-GLP-1 in pg/mL

  7. Change in lactate

    Time frame: 4 hours during each study intervention

    insulin in mmol/L

Secondary outcomes

  1. Explicit liking

    Time frame: 4 hours during each study intervention

    A visual analog scale ranging from 0 to 100 mm is utilized to evaluate the question, "How pleasant would it be to taste some of this food now?" with 0 indicating "not at all" and 100 signifying "extremely."

  2. Explicit wanting

    Time frame: 4 hours during each study intervention

    A visual analog scale ranging from 0 to 100 mm is utilized to evaluate the question, "How much do you want some of this food now?" with 0 indicating "not at all" and 100 signifying "extremely."

  3. Implicit wanting

    Time frame: 4 hours during each study intervention

    Participants are given a set of food image pairs and are asked to select their preference by answering the question, "Which food do you desire the most at the moment?". The implicit wanting calculation involves further consideration of response time data based on preference choices using a standardized equation.

  4. Relative preference

    Time frame: 4 hours during each study intervention

    Participants are given a set of food image pairs and are asked to select their preference by answering the question, "Which food do you desire the most at the moment?". The relative preference is the sum of the times each type of food is chosen, with a maximum value of 48 and a minimum value of 0.

  5. Fat appeal bias

    Time frame: 4 hours during each study intervention

    Fat preference (high or low) is calculated by subtracting the mean low-fat scores from the mean high-fat scores. Positive values suggest a preference for high-fat foods, while negative scores indicate a preference for low-fat or savory foods, and a score of 0 signifies an equal preference between fat content.

  6. Taste appeal bias

    Time frame: 4 hours during each study intervention

    Taste preference (savoury or sweet) is calculated by subtracting the mean savory scores from the mean sweet scores. Positive values suggest a preference for sweet foods, while negative scores indicate a preference for savory foods, and a score of 0 signifies an equal preference between taste categories.

  7. Change in TG

    Time frame: 4 hours during each study intervention

    TG in mg/dL

  8. Change in glucose

    Time frame: 4 hours during each study intervention

    glucose in mg/dL

  9. Change in insulin

    Time frame: 4 hours during each study intervention

    insulin in mU/L

  10. Sex hormones

    Time frame: 4 hours during each study intervention

    Sex hormones will be measured, such as estrogen and progesterone

  11. Energy intake

    Time frame: 3 days during each study intervention

    Participants will be required to record their diet for the day before, the current day, and the day following the experiment.

Sponsors and collaborators

Lead sponsor

National Taiwan Normal University

Other

Registry information

Official study title

The Effects of Resistance Exercise on Appetite Control, Food Reward, and Energy Intake in Different Menstrual Cycles

Important dates

Study start
2023
Primary completion
2024
Study completion
2024
First posted
Jan 17, 2024
Registry last updated
Jun 7, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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