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OpenTrials
Completed

NCT Number: NCT02985580

Effects of Blueberry Juice Consumption on Cognitive Function in Healthy Older People

Blueberries are rich in flavonoids that possess antioxidant and anti-inflammatory properties, which in rodent models are neuro-protective. The risk of developing dementia is reduced in people habitually consuming high flavonoid intakes, but data from human intervention studies is sparse. We therefore investigated whether 12 weeks of blueberry concentrate supplementation improved cognitive function in healthy elderly via increased brain activation and perfusion.

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Key information

Conditions

Cognitive Aging

Age range

60 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • aged 60-80y
  • Addenbrooke's Cognitive Examination III questionnaire > 88
  • Consuming 5 or less portions of fruit per day

Exclusion criteria

Addenbrooke's Cognitive Examination III questionnaire < 88 Contraindications for MRI Consuming more than 5 portions of fruit per day

Treatment and study plan

Blueberry

Dietary Supplement

Placebo

Dietary Supplement

Primary outcomes

  1. Brain perfusion

    Time frame: Change from baseline to 12 weeks dietary supplementation

    MRI - arterial spin labelling

Secondary outcomes

  1. Brain activation

    Time frame: Change from baseline to 12 weeks dietary supplementation

    fMRI whilst performing modified Stroop task

  2. Cognitive function tests

    Time frame: Change from baseline to 12 weeks dietary supplementation

    Cogstate battery of tests

  3. Blood biomarkers of inflammation

    Time frame: Change from baseline to 12 weeks dietary supplementation

    CRP, IL6,

  4. Blood biomarkers of oxidative stress

    Time frame: Change from baseline to 12 weeks dietary supplementation

    protein carbonyls, glutathione

  5. Blood biomarkers of neurogenesis

    Time frame: Change from baseline to 12 weeks dietary supplementation

    BDNF

Sponsors and collaborators

Lead sponsor

University of Exeter

Other

Registry information

Official study title

Effects of Blueberry Juice Consumption on Brain Activation and Perfusion in Healthy Older People

Important dates

Study start
2013
Primary completion
2014
Study completion
2014
First posted
Dec 7, 2016
Registry last updated
Dec 7, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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