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Completed

NCT Number: NCT05672771

The Effects of Mixed Working Memory Training on Subsequent Training Gains Among Older Adults

While an intellectually active and socially integrated lifestyle shows promise for promoting cognitive resilience, the mechanisms underlying any such effects are not well understood. The aim of the current project is test the implications of the "mutualism" hypothesis, which suggests that intellectual function emerges out of the reciprocal influence of growth in abilities as they are exercised in the ecology of everyday life. Such a view implies that improvement in one component will enhance the modifiability of a related component. An additional aim was to test the idea that mutualistic effects will be enhanced by more diverse training in related skills, such as interleaved training of multiple skills, relative to single-component training.

A "successive-enrichment" paradigm was developed to test this with working memory (WM) as the target for training given its centrality in models of attention, intellectual function, and everyday capacities such as reasoning and language comprehension. All participants receive the same target training, but the nature of the training that precedes it is manipulated. Outcome measures include pre- to posttest gains in working memory and episodic memory, as well as the rate of gain in learning the target task. The principle of enhanced mutualism would predict that more diverse experiences related to the target skill will enhance efficiency in acquiring the target skill.

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Key information

Conditions

Age range

60 year–90 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Beckman Institute

Urbana, Illinois, 61801, United States

About this study

Within conventional assessments of transfer that examine the effects of training on measures of function at a single time point, these ideas has not been tested. In this project, a "successive-enrichment" paradigm was used to examine improvement in cognitive skills as a function of different conditions for earlier training. The target for training is working memory (WM) given its centrality in models of attention, intellectual function, and everyday capacities such as reasoning and language comprehension.

In the successive-enrichment paradigm, all participants receive the same target training, but the nature of the training that precedes it is manipulated. Thus, in Phase 2, all participants are trained for 10 days on the reading span task (RdgS), in which the task is to verify sensibility in a set of sentences and retain in memory an alphabetic character presented after each sentence. The set size adapts to the participant's skill (in both accuracy of sensibility decisions and memory for the letter set). In Phase 1, participants are randomly assigned to one of four groups designed to test the assumption that related and diverse experiences with the target skill differentially enhance the rate of learning the new skill. In the Same Task (ST) control, participants train on the RdgS, and were expected to be at ceiling in Phase 2. In the Different Single condition (DS), participants trained on a WM task different from that in Phase 1 (the lexical decision span). In the Different Mixed (DM) condition, participants trained on two different interleaved WM tasks, the lexical decision span and the category span. In the non-WM Placebo Control (PC), participants train on a speeded lexical decision task (matched in materials and verbal decision component to the lexical decision span the but requiring no simultaneous memory.

Outcome measures include pre- to posttest gains in working memory and episodic memory, as well as the rate of gain in learning the RdgS in Phase 2. The PC and ST controls define the lower and upper limits of performance, respectively. The principle of enhanced mutualism would predict that the DM group will show more efficient learning of the RdgS in Phase 2 than the DS group, which will both show more efficient learning than the PC group.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Native English speakers or acquisition of English before age 6 yrs old
  • Self-report of hearing ability sufficient to engage with lab personnel
  • No stroke in the last 3 years
  • No current cancer treatment involving radiation or chemotherapy - No self-reported learning disability
  • No self-reported psychiatric disorder
  • Willingness to be randomly assigned to training conditions
  • No plans that would limit participation during the activity period
  • No participation in a cognitive intervention program in the last year

No additional Exclusion Criteria.

Treatment and study plan

Different Mixed Condition (DM)

Behavioral

Participants engage in home-based training on two working memory tasks, both different from those in the target task training. Goal is 10 days of training, with 4 8-min blocks of training each day.

Different Single Condition (DS)

Behavioral

Participants engage in home-based training on a working memory task that is different from that in the target task training. Goal is 10 days of training, with 4 8-min blocks of training each day.

Same Task (ST) Practice Control

Behavioral

Participants engage in home-based training on the exact same working memory tasks as that in the target task training. Goal is 10 days of training, with 4 8-min blocks of training each day.

Non-WM Placebo Control (PC)

Behavioral

Participants engage in home-based training on speeded verbal decision, which unlike the target task training, has no memory component. Goal is 10 days of training, with 4 8-min blocks of training each day.

Primary outcomes

  1. Change in Overall Working Memory

    Time frame: Change from baseline to 5-6 wks after pretest

    Average change in working memory from pre- to posttest in z-score units ("standard unit change"). For each working memory measure (Reading Span, Lexical Decision Span, Category Span, Operation Span, and Count Span), the change in z-score units was calculated [(posttest score - pretest score) / standard deviation of the scores at pretest)]. The score reported is the mean of these 5 values. A z-score of 0 represents no change from pretest to posttest; the unit is the standard deviations of the sample at pretest (e.g., a score 0.5 would indicate a half standard deviation improvement in overall working memory). There is no agreed upon standard of clinical significance for improvement in working memory

  2. Change in Reading Span

    Time frame: Change from Baseline to 5-6 weeks after pretest

    Change in Reading Span score from pre- to posttest in z-score units ("standard unit change"). The change in z-score units was calculated [(posttest score - pretest score) / standard deviation of the scores at pretest)]. A z-score of 0 represents no change from pretest to posttest; the unit is the standard deviations of the sample at pretest (e.g., a score 0.5 would indicate a half standard deviation improvement in overall working memory). There is no agreed upon standard of clinical significance for improvement in working memory

Secondary outcomes

  1. Training Gains on the Reading Span Task in Phase 2

    Time frame: 2 weeks

    In Phase 2, training data on the target task (Reading Span) is collected over 10 days. Training gains are estimated by the coefficients for the condition contrast by training interaction in a linear mixed effects model, in which mean working memory score across training days was modeled as a function of the Phase 1 training condition. Using the lme4 and lmerTest packages for R version 4.2.2, a mixed-effects linear regression model was employed to model the mean daily span score with condition and training day as the fixed factors, and a by-subject random intercept, using the restricted maximum likelihood (REML) method of estimation.

Sponsors and collaborators

Lead sponsor

University of Illinois at Urbana-Champaign

Other

Collaborators

  • National Institute on Aging (NIA)

Registry information

Acronym: MixedWM

Important dates

Study start
2020
Primary completion
2022
Study completion
2022
First posted
Jan 5, 2023
Registry last updated
Mar 28, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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