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Completed

NCT Number: NCT01580150

Effects of Berries on Post-meal Blood Sugar

The purpose of this study is to investigate whether berries are effective in lowering blood glucose and insulin responses to meals containing starch or sucrose.

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Key information

Conditions

Blood Glucose, Postprandial Blood Insulin, Postprandial Glucose Metabolism Disorders Hyperglycemia Hyperinsulinism Insulin Resistance Metabolic Diseases Nutritional and Metabolic Diseases

Age range

25 year–69 year

Study type

Interventional

Phase

Not applicable

Primary location

University of Eastern Finland

Kuopio, FI-70211, Finland

About this study

Berries are rich sources of various polyphenols which may be beneficial in the regulation of blood glucose. In vitro and animal studies have shown that polyphenols and polyphenol-rich extracts of foods, including berries, may inhibit digestion and absorption of carbohydrates and thereby suppress postprandial glycemia. However, current evidence on the effects of berries on postprandial glycemic responses in humans is limited.

The purpose of this study is to investigate the effects of berries on postprandial glycemic responses (blood glucose and insulin) to starch or sucrose in healthy subjects. It consists of five substudies each of which includes 2-4 meals with different berry species typically consumed in Finland and a reference meal without berries. The following combinations of carbohydrates and berries are studied:

  • Studies 1-2: white wheat bread (starch) is consumed with several berry species
  • Study 3: white wheat bread or rye bread is consumed with a mixture of berries
  • Study 4: sugar (sucrose) is consumed with berries and berry nectars
  • Study 5: a sugar-sweetened bakery product (starch + sucrose) is consumed with berries and berry nectar.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • BMI 20-28 kg/m2
  • normal fasting plasma glucose

Exclusion criteria

  • Smoking
  • Diabetes or other chronic disease
  • Antibiotic medication within the past 3 months
  • Blood donation within the past month

Treatment and study plan

Berries

Other

Meals containing starch (bread) or sucrose are consumed with berries (150 g) or berry nectars (300 mL).

No berries

Other

Meals containing starch (bread) or sucrose are consumed without berries.

Primary outcomes

  1. Plasma glucose

    Time frame: 0, 15, 30, 45, 60, 90, 120 minutes post-meal

  2. Plasma insulin

    Time frame: 0, 15, 30, 45, 60, 90, 120 minutes post-meal

Secondary outcomes

  1. Plasma free fatty acids

    Time frame: 0, 15, 30, 45, 60, 90, 120 minutes post-meal

Sponsors and collaborators

Lead sponsor

Marjukka Kolehmainen

Other

Registry information

Official study title

Effects of Berries on Postprandial Glycemic Responses to Sucrose and Starch

Acronym: SOMA

Important dates

Study start
2009
Primary completion
2012
Study completion
2012
First posted
Apr 18, 2012
Registry last updated
Apr 18, 2012

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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