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NCT Number: NCT03594188

Effects of Anesthetic Methods on Hepatic Cancer Cell Malignancy

Numerous studies found that anesthetic methods can influence the recurrence of tumor and the overall survival of patients after primary cancer surgery. Radiofrequency (RF) ablation is now widely used in clinic for treatment of hepatocellular carcinoma (HCC). Currently, diverse anesthetic methods, including general anesthesia (GA), epidural anesthesia and local anesthesia (LA), are used for RF ablation surgery. Using serum from HCC surgery patients randomized to receive either GA or LA during surgery, we investigated the effects of anesthetic methods on proliferation, migration and metastasis in HepG2 hepatic cancer cells in vitro.

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Key information

Conditions

Hepatocellular Carcinoma Adenocarcinoma Carcinoma Carcinoma, Hepatocellular Digestive System Diseases Digestive System Neoplasms Liver Diseases Liver Neoplasms Neoplasms Neoplasms by Histologic Type Neoplasms by Site Neoplasms, Glandular and Epithelial

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Renji Hospital affliated to Shanghai Jiaotong University School of Medicine

Shanghai, Shanghai Municipality, 200127, China

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • patients with a single primary liver tumor of 3cm or smaller, who are scheduled for RF ablation surgery

Exclusion criteria

  • less than 18 or more than 65 years old;
  • ASA Physical Status 4 or greater;
  • previous surgery in liver (including radiofrequency ablation);
  • severe systemic disease (heart, lung, kidney, or immune system);
  • INR>1.5 or platelet count <45,000 cells/mm3;
  • a history of addiction to opioids;
  • with known extension beyond the liver;
  • Child-Pugh Class C.

Treatment and study plan

anesthetic methods

Procedure

Patients will receive standard GA or LA for RF surgery.

Primary outcomes

  1. cell proliferation

    Time frame: 1 hour post-surgery

    HepG2 cells will be cultured with serum from patients undergoing RF ablation under GA or LA for 24h and cell proliferation will be measured

Secondary outcomes

  1. cell migration

    Time frame: 1 hour post-surgery

    HepG2 cells will be cultured with serum from patients undergoing RF ablation under GA or LA and cell migration will be measured

  2. cell metastasis

    Time frame: 1 hour post-surgery

    HepG2 cells will be cultured with serum from patients undergoing RF ablation under GA or LA and cell metastasis will be measured

Sponsors and collaborators

Lead sponsor

RenJi Hospital

Other

Registry information

Official study title

Effects of Serum From Hepatocellular Carcinoma Surgery Patients Under Different Anesthetic Methods on Hepatic Cancer Cell Malignancy in Vitro

Important dates

Study start
2018
Primary completion
2019
Study completion
2019
First posted
Jul 20, 2018
Registry last updated
Apr 6, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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