Effects of an Oral Nicotine Product in Smokeless Tobacco Users

Inclusion criteria

• Healthy (determined by self-report)
• Between the ages of 18-55
• Willing to provide informed consent, attend the lab sessions and abstain from tobacco/nicotine as required
• Agree to use designated products according to study protocol
• Smokeless tobacco users and must report using smokeless tobacco daily. Smokeless tobacco users must have a 'positive' cotinine cassette result to verify nicotine use

Exclusion criteria

• The following self-reported current, diagnosed medical condition(s): heart-related conditions (e.g., recent heart attack/stroke, coronary heart disease), severe immune system disorders (e.g., HIV/AIDS, multiple sclerosis), respiratory disorders (e.g., COPD, asthma), kidney diseases, liver diseases (e.g., cirrhosis), or seizures
• Other self-reported current, diagnosed medical conditions (e.g., diabetes, thyroid disease, Lyme disease) may be excluded after consultation with the PI and medical monitor: any medical condition/medication that may affect participant safety, study outcomes, or biomarker data will be excluded based on these consultations
• Self-reported current, diagnosed psychiatric conditions, and who are currently under the care of a physician for psychiatric conditions, or who report current psychiatric treatment or psychotropic medication use
• Not providing answers to questions related to inclusion/exclusion criteria
• Breast-feeding or pregnant women (pregnancy tested by urinalysis at screening
• Weigh less than 110 pounds
• Intend to quit tobacco/nicotine use in the next 30 days