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Completed

NCT Number: NCT03330366

Effects of Allium Hookeri on Blood Glucose

The researchers investigated the anti-diabetic effects of Allium hookeri root extract for Korean prediabetic participants.

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Key information

Conditions

PreDiabetes Diabetes Mellitus Endocrine System Diseases Glucose Metabolism Disorders Metabolic Diseases Nutritional and Metabolic Diseases Prediabetic State

Age range

20 year–70 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

About this study

Allium hookeri root is widely consumed as a vegetable and herbal medicine in Asia. Although the antidiabetic activities of Allium hookeri have been documented in animal studies, the improved effects of Allium hookeri on human are not clear. Therefore, in this study, the researchers investigated whether Allium hookeri root extract could be effective in reducing the risk of type 2 diabetes in individuals with prediabetes.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Fasting glucose 100~126 mg/dl

Exclusion criteria

  • Significant variation in weight (more 10%) in the past 3 months
  • Treatment by hypoglycemic and hypolipidemic drug therapy within the past three months
  • Type 1 diabetes or HbA1c>9.0%
  • Cardiovascular disease
  • Hypoglycemic agent, obesity medicine, and lipid lowering agent within past 6 months or blood sugar, obesity, and lipid improvement functional foods within past 2 monts
  • Pregnancy or breast feeding

Treatment and study plan

Allium hookeri extract

Dietary Supplement

take two capsules per day (486 mg/day) for 8 weeks

Other names: AH

Placebo

Dietary Supplement

take two capsules per day

Primary outcomes

  1. Changes of blood glucose during OGTT

    Time frame: 8 weeks

    Changes of fasting and postprandial glucose during OGTT were assessed before and after the intervention

Secondary outcomes

  1. Changes of blood insulin

    Time frame: 8 week

    Changes of blood insulin were assessed before and after the intervention

  2. Changes of C-peptide

    Time frame: 8 week

    Changes of C-peptide were assessed before and after the intervention

  3. Changes of HbA1c

    Time frame: 8 week

    Changes of HbA1c were assessed before and after the intervention

Sponsors and collaborators

Lead sponsor

Chonbuk National University Hospital

Other

Registry information

Official study title

An 8 Week, Randomized, Double-blind, Placebo-controlled Crossover Clinical Trial of Allium Hookeri Root Extract on Anti-diabetic Effects

Important dates

Study start
2015
Primary completion
2016
Study completion
2018
First posted
Nov 6, 2017
Registry last updated
Nov 20, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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