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Completed

NCT Number: NCT07710898

Amelioration of Lipid Profile Through Date Cider-vinegar Along With 5:2 Intermittent Fasting

A common metabolic abnormality in hyperglycemic individuals, dyslipidemia is strongly linked to an increased risk of cardiovascular illness. This study looked at how date cider vinegar and 5:2 intermittent fasting affected the lipid profile and metabolic indices of hyperglycemic patients

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Key information

Age range

35 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

The University of Lahore

Lahore, Pakistan

About this study

The target population was adults between the ages of 35 and 65 years who are receiving outpatient care at a hospital or clinic with a diagnosis of either mild to moderate hypertension, dyslipidemia or pre-diabetes. Once consent was given, participants were then be randomly assigned to receive the prescribed intervention or act as a control. The intervention period was 12 weeks.

Participants in the experimental groups received date cider vinegar supplementation, with one group additionally following the 5:2 intermittent fasting protocol. The control group received standard dietary advice without vinegar supplementation or fasting intervention. Participants were instructed to follow the assigned intervention daily according to the study protocol. Weekly follow-up visits were conducted to monitor dietary compliance, record self-reported adherence, and assess health outcomes including lipid profile, body weight,and blood pressure. Usual dietary intake was also monitored to ensure consistency and adherence to the intervention.

At baseline, nutritional assessment based on weight and height, BMI, waist circumference, blood pressure, fasting blood glucose, lipid panels (HDL, LDL, total cholesterol, triglycerides), and dietary intake analysis were done. After 12 weeks of intervention all the measurements that were done again to compare the results pre- and post-intervention.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • The inclusion criterion was target adults with both gender aged 35-65 years.
  • Adults with a diagnosis of mild to moderate hypertension
  • Mild hypertension (140-159/90-99 mm Hg)
  • Moderate hypertension (160-179/100-109 mm Hg)
  • Adults having mild to moderate alterations in lipid profile
  • Triglycerides: 150 to 499 mg/dL
  • LDL-C levels: Mild Alteration (130 to 159 mg/dL) and Moderate Alteration (160 to 189 mg/dL)
  • Adults with pre-diabetes (hbA1c= 5.6-6.4%) were used.
  • Patients were solicited from hospital.

Exclusion criteria

  • Any Lactating and pregnant women were not included.
  • Any person allergic to citric acid.
  • Adults suffering from critical health conditions, including cancer.

Treatment and study plan

Control Group (T 0 )

Drug

The control group received standard dietary advice without vinegar supplementation or fasting intervention.

Experimental Group (T 1 )

Dietary Supplement

Participants were advised to take 15 ml of Date Cider Vinegar (DCV) diluted in 1 cup (250ml) of water 15 minutes before breakfast and dinner daily for a duration of 3 months.

Experimental Group (T 2 )

Combination Product

Participants were advised to follow 5:2 Intermittent Fasting (two non-consecutive fasting days per week) along with DCV intervention for a duration of 3 months.

15 ml of DCV was diluted in 1 cup of water and It was taken 15 minutes before breakfast and dinner daily.

Primary outcomes

  1. Body Mass Index

    Time frame: 3 months

    BMI was calculated by dividing weight (in kg) by the square of height (in meters).

Secondary outcomes

  1. Blood pressure

    Time frame: 3 months

    Blood pressure measurements will be taken using an automated sphygmomanometer, with systolic pressure and diastolic pressure being measured while sitting after a 5-minute rest. The average of three readings were used for analysis.

  2. Lipid Profile

    Time frame: 3 months

    Total cholesterol, low-density lipoprotein cholesterol (LDL-C), triglycerides, and high-density lipoprotein cholesterol (HDL-C) levels were measured using enzymatic methods with commercial test kits.

Sponsors and collaborators

Lead sponsor

University of Lahore

Other

Registry information

Official study title

Amelioration of Lipid Profile Through Date Cider-vinegar Along With 5:2 Intermittent Fasting Among Prediabetic Individuals

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Jul 17, 2026
Registry last updated
Jul 17, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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