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Completed

NCT Number: NCT01738568

Effects of Aging and Aerobic Exercise Training on Brain Glucose Metabolism

Aging is associated with a loss of brain function and conditions such as dementia and Alzheimer's disease. It is likely that decreased brain metabolism is contributing to the progression of age related degenerative diseases. Aerobic exercise training can increase brain volumes and is associated with decreased risk for degenerative brain conditions. However, little is know about the changes that occur to brain metabolism with aerobic training and aging.

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Key information

Conditions

Dementia Brain Diseases Central Nervous System Diseases Mental Disorders Nervous System Diseases Neurocognitive Disorders

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Mayo Clinic in Rochester

Rochester, Minnesota, 55905, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Healthy sedentary adults aged 18-30 or 65-80 years of all ethnicities will be eligible. Pregnant women, children, prisoners or other at risk populations will not be recruited.

Inclusion criteria

  • Age 18-30 years or 65-80 years

Exclusion criteria

  • Body mass index (BMI) >31 kg/m2
  • Smoking
  • Pregnancy
  • Participation in structured exercise (>2 times per week for 30 minutes or longer)
  • Cardiovascular, metabolic (type 2 diabetes, fasting plasma glucose at or above 110 mg/dL and untreated hypo- or hyperthyroidism) or renal disease
  • Orthopedic problems that would keep them from being able to ride an exercise bicycle, lift weights or do a combination of these exercise
  • Medications that are known to impact on mitochondrial function: Corticosteroids, opiates, benzodiazepines, tricyclic antidepressants, beta blockers, sulfonylureas, insulin, anticoagulants, barbiturates, insulin sensitizers, fibrates (PPAR gamma agonist)
  • Claustrophobia

Treatment and study plan

High intensity aerobic training

Behavioral

High intensity aerobic interval training will be performed 12-weeks. Exercise training will last 1 hour per day, 5 days per week and include high intensity interval cycling at ~70-95% maximum workload for 4 minutes followed by 3 minutes of rest.

Sedentary Control

Behavioral

Sedentary control participants will not perform any regular exercise for 12-weeks.

Primary outcomes

  1. Change in Brain Glucose Uptake

    Time frame: 12 weeks

    The investigators will assess brain glucose uptake using positron emission tomography at baseline and following 12-weeks of either aerobic exercise training or sedentary control period.

Sponsors and collaborators

Lead sponsor

Mayo Clinic

Other

Registry information

Official study title

Effect of Aging and Aerobic Exercise Training on Brain Glucose Metabolism

Important dates

Study start
2012
Primary completion
2015
Study completion
2015
First posted
Nov 30, 2012
Registry last updated
Aug 30, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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