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Completed

NCT Number: NCT04180787

Effects of a Caffeine- and Protein-Containing Coffee Beverage on Metabolism and Muscular Performance

The purpose of this randomized, double-blind, crossover study is to investigate the effects of Bang® Keto Coffee on resting and post-exercise metabolism and muscular performance during lower body resistance exercise.

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Key information

Conditions

Exercise Performance Metabolism

Age range

18 year–40 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Department of Kinesiology & Sport Management

Lubbock, Texas, 79409, United States

About this study

Resistance-trained males and females will be recruited for participation in a randomized, double-bind, crossover trial. After providing informed consent, each participant will undergo a familiarization session to become accustomed to the study procedures. Following familiarization, each participant will complete two laboratory visits consisting of metabolism and exercise performance assessments. In both visits, a baseline assessment of resting metabolic rate (RMR) and respiratory exchange ratio (RER) will be conducted using indirect calorimetry. Following the initial RMR assessment, each participant will ingest a coffee flavored beverage, either VPX Bang® Keto Coffee or a flavor-matched placebo. After beverage consumption, the participant will return to the supine position and rest prior to initiation of the second RMR assessment. Immediately following the second RMR assessment, the participant will begin a 5-minute dynamic bodyweight warm up. Participants will then begin squat testing procedures on a mechanized squat device. After completing the squat testing, participants will complete a standard 1-repetition maximum and repetitions to failure using a plate-loaded hip sled machine. Following the hip sled testing, participants will repeat the mechanized squat testing. Following completion of the exercise testing, a third and final RMR assessment will be performed. Following successful completion of the first condition, each participant will enter a wash out period, after which the visit will be repeated with ingestion of the alternative beverage.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Between the ages of 18 and 40
  • Generally healthy (defined as an absence of any disease or medical condition which could potentially be negatively affected by consumption of the commercially available dietary supplement of performance of exercise, including but not limited to musculoskeletal or cardiovascular diseases).
  • Resistance-trained, defined as completing 3+ resistance training sessions per week for at least one year and including at least weekly training of the lower body through a multi-joint exercise such as the squat or leg press.
  • Regular caffeine consumption, defined as an average self-reported daily intake of 200+ mg of caffeine, which is equivalent to approximately 2 cups of coffee.

Exclusion criteria

  • Failing to meet any of the aforementioned inclusion criteria.
  • Pregnant or breastfeeding (for female participants)
  • Taking prescription medication which could reasonably make participation unsafe for the participant or influence study outcomes
  • An inability to complete lower body resistance exercise due to injury or medical condition
  • Self-reported caffeine sensitivity, as indicated by unwanted side effects when caffeine is consumed.
  • Allergy to any of the ingredients in the commercially available dietary supplement
  • Self-reported claustrophobia (due to metabolism testing)

Treatment and study plan

Beverage Consumption

Dietary Supplement

Participants will consume either VPX Bang® Keto Coffee beverage or flavor-matched placebo beverage in each condition.

Primary outcomes

  1. Isometric Force Production

    Time frame: Assessed approximately 45 minutes after beverage ingestion

    Isometric force production on mechanized squat device

  2. Isometric Force Production

    Time frame: Assessed approximately 80 minutes after beverage ingestion

    Isometric force production on mechanized squat device

  3. Isokinetic Force Production

    Time frame: Assessed approximately 45 minutes after beverage ingestion

    Isokinetic force production on mechanized squat device

  4. Isokinetic Force Production

    Time frame: Assessed approximately 80 minutes after beverage ingestion

    Isokinetic force production on mechanized squat device.

  5. Maximal Lower Body Strength

    Time frame: Assessed approximately 75 minutes after beverage ingestion

    One-repetition maximum on hip sled machine

  6. Maximal Lower Body Endurance

    Time frame: Assessed approximately 75 minutes after beverage ingestion (following maximal lower body strength testing)

    Repetitions to failure on hip sled machine

  7. Change in Metabolic Rate

    Time frame: Change in metabolic rate between: 1) before beverage ingestion (baseline) and 2) beginning approximately 10 minutes after completion of beverage ingestion

    Metabolic rate assessed via indirect calorimetry

  8. Change in Metabolic Rate

    Time frame: Change in metabolic rate between: 1) before beverage ingestion (baseline) and 2) beginning approximately 5 minutes after completion of all exercise testing

    Metabolic rate assessed via indirect calorimetry

  9. Change in Respiratory Exchange Ratio

    Time frame: Change in respiratory exchange ratio between: 1) before beverage ingestion (baseline) and 2) beginning approximately 10 minutes after completion of beverage ingestion

    Respiratory exchange ratio as assessed via indirect calorimetry

  10. Change in Respiratory Exchange Ratio

    Time frame: Change in respiratory exchange ratio between: 1) before beverage ingestion (baseline) and 2) beginning approximately 5 minutes after completion of all exercise testing.

    Respiratory exchange ratio as assessed via indirect calorimetry

Sponsors and collaborators

Lead sponsor

Texas Tech University

Other

Collaborators

  • Vital Pharmaceuticals, Inc.

Registry information

Important dates

Study start
2019
Primary completion
2020
Study completion
2020
First posted
Nov 29, 2019
Registry last updated
May 7, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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