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Completed

NCT Number: NCT04308876

Effectiveness of Manual Therapy and Strengthening Exercises in Hemophilic Arthropathy of the Elbow Joint

Manual treatment involves techniques based on the principles of moving the joint faces and separating the joint gap, and soft tissues mobilization techniques. The use of manual therapy in hemophilia is gradually increasing although it previously described as a contraindication. The utility and use of strengthening exercises in hemophilia has been going on for a long time. In this study, the effect of manual therapy and strengthening exercises joint was investigated in hemophilic arthropathy of the elbow.

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Key information

Conditions

Hemophilia Arthritis Behavior Blood Coagulation Disorders Blood Coagulation Disorders, Inherited Coagulation Protein Disorders Congenital, Hereditary, and Neonatal Diseases and Abnormalities Genetic Diseases, Inborn Hematologic Diseases Hemic and Lymphatic Diseases Hemophilia A Hemorrhagic Disorders Joint Diseases Motor Activity Musculoskeletal Diseases

Age range

12 year–35 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

Cukurova University

Adana, Sarıcam, Turkey (Türkiye)

About this study

The aim of this study was to investigate the effects of strengthening exercises and manual therapy on bleeding frequency, pain, range of motion, muscle strength, arm circumference, joint health, functionality and quality of life in the physiotherapy and rehabilitation of hemophilic arthropathy of the elbow. Seventeen adolescent and young adult hemophilic individuals aged 12-30 years with elbow arthropathy were included in the study. The individuals were divided into the two groups via simple randomisation as Manuel Therapy and Exercise Group (MTEG) and Home Exercise Group (HEG). The individuals in HEG were given strengthening exercises as a home program. Those in the MTEG were applied manual therapy by the physiotherapist and were given supervised strengthening exercises. All treatments were performed 3 times a week for 5 weeks totally 15 sessions. Frequency of bleeding was evaluated with number of bleeding in the last 5 weeks. Numerical Pain Scale was used for activity and resting pain. Range of motion and muscle strength were measured with universal goniometer and digital dynamometer, respectively. The Quick-DASH questionnaire and Oxford Elbow Score were used for the functionality of the upper extremity and quality of life, respectively. The joint health status was evaluated with Hemophilia Joint Health Score-Elbow Point and Hospital for Special Surgery-Elbow Scoring System. Evaluations were made by the same physiotherapist before and after treatment.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Having signs of hemophilic arthropathy in one or both elbow joints, Being between the ages of 12-30 (Adolescent and young adult), Receiving prophylactic factor replacement therapy.

Exclusion criteria

  • Having undergone any surgical procedure for elbow arthropathy, Having an orthopedic problem, such as a fracture, ligament or tendon injury, related to the upper limb in the past year, Receiving physiotherapy and rehabilitation for the elbow joint in the last 6 months

Treatment and study plan

Manual therapy

Other

Manual therapy includes techniques applied to elbow joints and surrounding tissues

Strengthening Exercises

Other

Strengthening exercises used in this study includes resistant exercises to increase muscle strength of upper extremity

Primary outcomes

  1. Hemophilia Joint Health Score

    Time frame: 5 week

    We used the elbow point of Joint Health Status. Elbow Point is scored 0-20. A high score indicates that arthropathy findings worsen

  2. Frequency of bleeding

    Time frame: 5 week

    It was evaluated wit bleeding number in elbow joint over last 5 week

  3. Numerical Pain Scale

    Time frame: 5 week

    It was used for evaluation of activity and resting pain.

Secondary outcomes

  1. Range of motion

    Time frame: 5 week

    It was measured with universal goniometer.

  2. Muscle strength

    Time frame: 5 week

    It was measured with digital dynamometer (Lafayette hand-held dynamometer)

  3. Functionality of the upper extremity

    Time frame: 5 week

    Quick-Disability of Arm, Shoulder and Hand questionnaire was used.

  4. Oxford Elbow Score

    Time frame: 5 week

    It was used for evaluation of Quality of life.

  5. Physical status of the elbow

    Time frame: 5 week

    Hospital for Special Surgery-Elbow Scoring System was used.

Sponsors and collaborators

Lead sponsor

Necmettin Erbakan University

Other

Registry information

Official study title

Investigation of Effectiveness of Manual Therapy and Strengthening Exercises in Physiotherapy and Rehabilitation of Hemophilic Arthropathy of the Elbow

Important dates

Study start
2018
Primary completion
2019
Study completion
2020
First posted
Mar 16, 2020
Registry last updated
Mar 16, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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