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NCT Number: NCT07325942

Effectiveness of Low -Versus High -Volume High -Intensity Interval Training in Patients With Chronic Heart Failure

this study aims to investigate the effect of low vs high volume- high intensity interval training on functional capacity and quality of life in chronic heart failure patients

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Key information

Conditions

Chronic Heart Failure

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Chronic stable heart failure patient with reduced ejection fraction (EF <40)
  • Age Above 18 years old
  • Both males and females
  • The ability to provide informed consent

Exclusion criteria

  • Based on the Scientific Statement from the American Heart Association: contraindications for exercise Testing and Training. (Fletcher et al., 2013)
  • Acute myocardial infarction (MI), within 2 days
  • Ongoing unstable angina
  • Uncontrolled cardiac tachy or brady arrhythmia with hemodynamic compromise
  • Active endocarditis
  • Symptomatic severe aortic stenosis
  • Decompensated heart failure
  • Acute pulmonary embolism, pulmonary infarction, or deep vein thrombosis
  • Acute myocarditis or pericarditis
  • Acute aortic dissection
  • Physical disability that precludes safe and adequate testing or training
  • Known obstructive left main coronary artery stenosis
  • Hypertrophic obstructive cardiomyopathy with severe resting gradient
  • Recent stroke or transient ischemic attack
  • Mental impairment with limited ability to cooperate
  • Resting hypertension with systolic or diastolic blood pressures >200/110 mmHg
  • Uncorrected medical conditions, such as significant anemia, important electrolyte imbalance, and hyperthyroidism
  • Acute decompensated heart failure NYHA class IV

Treatment and study plan

Low-volume high intensity interval training

Other

Low-volume HIIT (LV-HIIT) is a particularly time-efficient subtype of interval training, which has gained increasing attention in recent years. As per the previous definition, these brief training protocols typically involve≤10 min of intense exercise within a session lasting≤30 min including warm-up, recovery phases between intervals, and cool-down

High volume high intensity interval training

Other

long (2-4 min) bouts of high (not maximum) intensity exercise interspersed with recovery periods which have wide varieties in the protocols according to the intensity, duration, and number of intervals performed

Standard Medical Treatment

Drug

standard medical treatment for chronic heart failure as per international guidlines

Primary outcomes

  1. 6 minute walk test

    Time frame: at enrolment and at the end of treatment at 8 weeks

    self-paced submaximal field exercise test to assess submaximal functional capacity of the patient , the distance walked by the patient for six minutes will be measured by meters

  2. 2D Echocardiographic parameters

    Time frame: at enrollment and at the end of treatment at 8 weeks

    Left ventricle geometry: left ventricular end-diastolic diameter (LVEDD) mm, left ventricular end-systolic diameter (LVESD) mm, left ventricular end-systolic volume (LVESV) ml. and, left ventricular end-diastolic volume (LVEDV) ml.

    Left ventricle Systolic function: left ventricular ejection fraction (LVEF) % Left ventricle Diastolic function :E wave cm/s: early diastolic mitral inflow velocity, A wave cm/s: diastolic mitral inflow velocity during late atrial contraction , E/A ratio

Secondary outcomes

  1. Minnesota living with heart failure questionnaire (MLHFQ)

    Time frame: at enrollment and at the end of treatment at 8 weeks

    The Minnesota Living with Heart Failure Questionnaire (MLHFQ) is the tool most widely used and recognized to assess HRQOL in adults with Hf, was developed in 1987 by Thomas Rector, focusing on the underlying relationship between pathophysiology, symptoms, functional limitations, and psychological distress, it measures the impacts of symptoms and treatment on different dimensions of HRQOL in HF patients.

Study contacts

Contact information is provided by the study sponsor or research team.

Aya I Elshenawy

CONTACT

[email protected]

+01098811085

Sponsors and collaborators

Lead sponsor

Cairo University

Other

Registry information

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Jan 8, 2026
Registry last updated
Jan 8, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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