Effect of Whole-Body Vibration on Plasma Sclerostin Level

Whole-body vibration has a strong osteogenic effect. The cyclic mechanical loading to the bone stimulates the osteocytes.

Sclerostin, the protein product of the SOST gene, is an osteocyte-specific cysteine knot-secreted glycoprotein that is a potent inhibitor of bone formation. Sost/sclerostin levels have been reported to be reduced by mechanical stimulation.

The aim of this study is to investigate effect of whole-body vibration on plasma sclerostin level in healthy young adult women.

Inclusion criteria

• Healthy women,
• Women with ages varying between 20 and 40 years
• Right-handed women

Exclusion criteria

• Lower extremity problems

• Orthopedic problems: shortness of legs, congenital anomalies, etc.
• Joint disease (arthritis, joint prosthesis, etc.)
• Other painful pathologies in the lower extremities (fractures, tendinitis,bursitis, etc.)
• Circulation problems in the lower extremities
• Dorsolumbar diseases: Vertebral fract, disc hernias, spondylodiskitis, etc.
• Systemic disease cases

• Systemic bone disease: osteoporosis, osteomalacia, Paget's disease
• Hypertension (>135 mmHg systolic, >85 mmHg diastolic)
• Heart dis.(coronary dis, conduction/rhythm prob, cardiac pacemaker)
• Infectious diseases
• Endocrine diseases (Diabetes mellitus etc)
• Neurological diseases (CNS problems, peripheral neuropathy)
• Menstrual cycle disorders, amenorrhea, lactation, oral contraceptive use
• Cases during the ovulatory period (11-16th day of menses)
• Obesity (BMI >30 kg/m2) or low BMI (BMI <20 kg/m2)
• Vertigo
• Cognitive function disorders
• Women whose blood samples were not taken in the time planned
• Women whose blood samples hemolyzed