Effect of Whey Protein Supplementation on Postoperative Outcomes After Gynecological Cancer Surgery

During admission, Participants will be randomized by a computer program into two groups as the whey protein supplement group and control group. Both groups will undergo nutritional assessment on the first day of admission before surgery by the Rajavithi Subjective Global Assessment tool and serum albumin level.

The whey protein supplement group : participants will receive isolated whey protein in the form of two packets of isolated whey protein powder (each packet containing 11.5 grams, totaling to 23 grams) mixed with water in a 350 milliliter drinking bottle at 6.00 p.m. on first day before operation. After the operation, participants will receive the same form of protein supplement as before surgery at 6.00 a.m. on the first day after operation.

The control group : participants will receive standard care, which includes fasting from food after midnight on the night before surgery and other standard surgical protocols.

After surgery, participants will be assessed based on

• Intraoperative outcomes, which include the duration of surgery, intraoperative blood loss, and intraoperative complications.
• The postoperative outcomes, which include length of hospital stay, duration of stay in the intensive care unit (ICU), postoperative complications, postoperative pain, time to first ambulation , time to first flatus , nausea and vomiting symptoms, increased requests for pain medication, fever more than 24 hours after surgery , wound infection and readmission.
• The nutritional status outcomes, assessed through serum albumin levels before surgery and on the 3rd day after surgery in both groups of participants.
• The side effects of whey protein supplement, in the experimental group participants, which will evaluate include allergic reactions, nausea, vomiting, abdominal discomfort, bloating, headache, reduced appetite, elevated creatinine levels, and increased liver function levels on the 3rd day and two weeks after surgery.

Inclusion criteria

• A Woman who suspected or diagnosed with ovarian and endometrial Cancer
• A Woman who candidates for elective Surgical staging of Laparotomy operation in Rajavithi hospital
• Aged 18-70 years old
• Can communicate and understand Thai language very well
• A woman voluntarily participated in the research

Exclusion criteria

• Allergy to whey protein and protein product such as cow milk and egg
• A Woman who diagnosed with Hypertension, Diabetes Mellitus, Chronic Kidney Disease, Heart disease and Chronic liver disease
• A Woman who expected difficult operation such as severe pelvic adhesion or required other surgeon for co-evaluation
• Pregnant woman or breastfeeding
• A Woman who denied surgery
• A Woman who currently take a protein supplement
• A Woman who take Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) , Bisphosphonates, Levodopa ,Tetracycline and Quinolone