Effect of VPro5 Therapy on Clear Aligner Therapy

Inclusion criteria

• Subject must be 18 - 45 years of age
• Subject is willing and able to comply with all study procedures and sign Informed consent/HIPAA forms
• Subject must have complete adult dentition (excluding third molars)
• Subjects must have class I malocclusion or mild class II/III malocclusions
• Subject is at least one month into aligner treatment.
• Subject has history of and current healthy oral hygiene (PD is<4mm, GI<1, and PI=1)

Exclusion criteria

• Subjects who have received periodontal treatment in the previous 6 months
• Subjects who are taking medication that could affect the level of inflammation, such as chronic antibiotics, phenytoin, cyclosporin, ant-inflammatory drugs, systemic corticosteroids, or calcium channel blockers.
• Subjects missing adult teeth (except the 3rd molars) or with severe class II or class III malocclusion.
• Subjects with skeletal class I but extreme dental malocclusion
• Severe crowding that require extraction
• More than 4 mm positive overjet and more than 2 mm negative overjet
• Extreme deep bite (more than 90%);
• Severe openbite (more than 2 mm)
• Pregnant women
• Subjects do not have any systemic diseases effecting bone metabolism
• Smoking
• Vulnerable subjects per IRB definitions
• Subjects with current caries
• Subjects that require interproximal reduction or attachments during the study period
• Subjects who are non-compliant regarding aligner wear or VPro5 recommended daily usage