Skip to main content
OpenTrials
Not Yet Recruiting

NCT Number: NCT07520253

Effect of Virtual Reality on Cortical Reorganization and Upper Extremity Functional Recovery in Patients With Subacute Stroke

The purposes of the study are:

1. To investigate the effect of virtual reality in patients with subacute stage of Stroke on cortical reorganization. 2. To investigate the effect of virtual reality in patients with subacute stage of Stroke on upper extremity functional recovery.

Not Yet Recruiting

Trial opening soon.

Get Notified

Key information

Conditions

Stroke Brain Diseases Cardiovascular Diseases Central Nervous System Diseases Cerebrovascular Disorders Nervous System Diseases Vascular Diseases

Age range

50 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Faculty of Physical Therapy, Cairo University, Egypt

Cairo, 12613, Egypt

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • • Age ranges from 50 to 65 years.
  • Both sexes (male and female).
  • First stroke ever (ischemic or hemorrhagic) within the last three months.
  • Clinical diagnosis of subacute stroke confirmed by neuroimaging (CT / MRI).
  • Hemiparetic shoulder power more than three according to Medical Research Council Scale (MRC) (James, 2007).
  • Patients who are able to manipulate the Wii remote control.
  • Muscle tone grade 1 to 1+ (Mild to Moderate) spasticity for shoulder joint according to Modified Ashworth Scale (Meseguer et al., 2018).
  • Participants are in normal cognitive and psychological status according to Montreal Cognitive Assessment screening (Hawkins et al., 2014).

Exclusion criteria

  • • Patients having severe arm or shoulder pain or symptomatic shoulder sublaxation.
  • Contractures or shoulder deformities.
  • Patients who have previous experience in using Wii.
  • Patients with problems that may interfere with using Wii suchas epilepsy, visual impairments, apraxia and/or spatial neglect

Treatment and study plan

Virtual Reality

Other

Twenty patients with subacute stroke will receive conventional physical therapy program and virtual reality through Nintendo Wii The patient will hold the Wii remote in his hand to move the Avatar on the screen and practice the exercise Figure.6. If the patient cannot hold the Wii remote in his hand it will be strapped to his hand. A full instruction according to every game will be explained to the patients explaining every game rules and how to perform and what is the goal of each game. The patient will have one trial in every game to perform before setting the time. Screen /projector will be positioned at eye level of each patient and a Chair for sitting or standing according to the patient, The patient will select three games from Wii sports (Tennis- Golf- Boxing-Baseball) then patients will be given a trial of playing each game to be familiar with it after that they will be given one hour practice 20 minutes for each game for six weeks and three times per week (18 sessions)

Other names: Exergaming using Nintendo WII

Conventional physical therapy program

Other

Patients will have conventional physical therapy program as follow :

Range of motion (ROM) and stretching begin with passive ROM to all joints of the upper limb (10 repetitions × 2 sets), followed by active-assisted ROM using a stick or the unaffected limb. Stretching is performed for 30-60 seconds, 3-5 repetitions.Strengthening exercises focus on isometric contractions of scapular stabilizers, deltoid, and biceps/triceps, holding 5-10 seconds × 10 repetitions, along with isotonic exercises using therabands or light weights (0.5-1 kg) for 8-12 repetitions × 2-3 sets. Activities of daily living (ADL) training involve self-care practices including grooming, eating, and buttoning, as well as task-specific training such as reaching, grasping, and releasing real objects. Each ADL task is practiced for 15-20 minutes, with 1-2 tasks per session.Scapular stability exercises include graded practice with large to small objects, bimanual training (e.g., holding a bowl while stirring)

Primary outcomes

  1. Upper Extremity Functional Recovery

    Time frame: 6 months

    Upper Extremity Functional Recovery will be assessed by Chedoke Arm and Hand Activity Inventory-7 item version (CAHAI-7). CAHAI-7 assesses the affected arm and hand during bilateral tasks by asking the person to complete seven specific activities. Each item of the CAHAI is scored on a 7-point quantitative scale ranging from 7 to 49, with higher scores reflecting greater functional recovery

  2. Cortical Reorganization

    Time frame: 6 months

    Cortical Reorganization will be assessed by Quantitative Electroencephalography (QEEG) QEEG indices can give meaningful prognostic information of motor and functional recovery in patients with stroke. Delta Alpha Ratio (DAR) and Delta Theta to Alpha Beta Ratio (DTABR) are quantitative EEG (QEEG) indices used to measure brain electrical activity. Lower values of DAR and DTABR are associated with better recovery in patients with brain injury.

  3. Gross manual dexterity

    Time frame: 6 months

    Gross manual dexterity will be assessed by Box and Block test (BBT). BBT contains a wooden box that is divided into two sections and the patient is asked to move the blocks from one side of to the other side. The BBT score represents the number of blocks successfully moved from one side of the box to the other within 60 seconds. A higher score indicates greater manual dexterity

Study contacts

Contact information is provided by the study sponsor or research team.

ABEER ABO BAKR ABDELKADER ELWISHY PROF. DR., Professor

CONTACT

[email protected]

+201228088835

MOHAMMED RAMADAN IBRAHIM MOHAMMED Mohammed, M.S.C

CONTACT

[email protected]

+201004345510

Sponsors and collaborators

Lead sponsor

Cairo University

Other

Registry information

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Apr 9, 2026
Registry last updated
Apr 9, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.