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NCT Number: NCT07003230

Effect of Vegan Diet on Microbiome and Metabolism

The goal of this interventional study is to investigate how vegan diet affects health in healthy volunteers, Men and women ages 20 - 30 years old. The main questions it aims to answer are:

Change in Microbial community composition and metabolic alterations Changes in plasma metabolic profile. Researchers will compare changes in microbiota and plasma metabolites profile to see the influence of vegan diet in health. In the dietary trial, participants were first assigned to a 2-week omnivorous diet phase, then switched to a 2-week vegetarian diet phase

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Key information

Conditions

Vegan Diet

Age range

20 year–30 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Zhujiang hospital

Guangzhou, Guangdong, 510515, China

Location contact

Zhujiang hospital

CONTACT

[email protected]

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

healthe Participants, ages 20-30 years old

Exclusion criteria

  • Oral antibiotic use or acute/chronic inflammation within the past 3 months;
  • Hormone intake within the past 3 months;
  • Use of any known interfering medications (e.g., insulin, glibenclamide, indomethacin, phentolamine, furosemide, phenytoin sodium, cortisone, etc.) or probiotics within the past month that may affect glucose or lipid metabolism;
  • Smoking or alcohol consumption;
  • Uncontrolled mental disorders (including a history of psychiatric hospitalization);
  • Currently participating in a weight loss or weight management program;
  • Following a special or medically prescribed diet (e.g., for celiac disease);
  • Comorbid cardiac or renal insufficiency;
  • Chronic constipation;
  • Hypertension;
  • Diabetes mellitus.

Treatment and study plan

vegan and omnivorous diet

Dietary Supplement

Participants underwent a 2-week omnivorous diet intervention, followed by a 2-week vegan diet intervention

Primary outcomes

  1. Gut microbiota composition in twenty participants

    Time frame: 14days，28days

    16S rDNA sequencing technology was used to identify the structural and functional changes of intestinal microbiota before and after vegan diet.

Secondary outcomes

  1. Metabolomic profile of twenty participants in serum and feces

    Time frame: 14days, 28days

    To determine changes of the metabolomic profile in feces and serum after vegan diet

Study contacts

Contact information is provided by the study sponsor or research team.

Zhanguo Liu

CONTACT

[email protected]

+86 13425766255

Sponsors and collaborators

Lead sponsor

Zhujiang Hospital

Other

Registry information

Important dates

Study start
2025
Primary completion
2025
Study completion
2025
First posted
Jun 4, 2025
Registry last updated
Jun 4, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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