Effect of TXA on Reducing Bruising After Filler Injection

The overall purpose of this study is to evaluate the safety and efficacy of co-administration of TXA with HA in reducing swelling, bruising and pain after facial injection. Researchers will do this by comparing HA to HA+TXA in participants undergoing facial filler injections. Participants undergoing facial filler injections almost always have the same type of injection performed bilaterally in order to maintain symmetry. This provides a unique opportunity where participants can serve as their own controls. Therefore, researchers have designed this as a half face study. Participants will be injected with HA on half of their face and the other half of the face will be injected with HA+TXA. Researchers will then assess swelling, bruising, pain, and overall satisfaction using participant self-reported surveys, physician surveys, and review of medical records.

Inclusion criteria

• Age equal to or greater than 18 but less than or equal to 89 years.
• Participants interested in facial filler (HA) injection.
• English speaking.

Exclusion criteria

• Minors or under the age of 18
• Participant over the age of 89
• Pregnant or breast-feeding women
• Individuals unable to give consent due to another condition such as impaired decision-making capacity.
• Individuals with a history of a thrombotic event (DVT, PE, stroke, MI) or genetic disorder that increases risk of thrombosis
• Participants undergoing unilateral facial filler (HA) injection
• Participants with history of hypersensitivity to TXA or any of the other ingredients
• Participants that are on current therapeutic anticoagulation therapy and aspirin use
• Participants with stage 2 or greater renal failure
• Participants on hemodialysis or peritoneal dialysis
• History of diabetes or seizures
• Current tobacco smokers
• Acquired defective color vision