Efficacy at One Year of Combined Injections of Plasma Rich in Platelets and Hyaluronic Acid in Knee Osteoarthritis

The French Society of Rheumatology cannot rule on the value of intra-articular injections of PRP due to the lack of hindsight and insufficient data. In fact, the injection protocols are very heterogeneous in terms of preparation method, the presence or not of leukocytes, the number of centrifugations, the volume injected, the ultrasound guidance, which makes it difficult to analyze the literature. The investigator objective is therefore to evaluate the effectiveness of combined injections of PRP and hyaluronic acid.

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Key information

Conditions

Knee Osteoarthritis Arthritis Hyaluronic Acid Joint Diseases Musculoskeletal Diseases Osteoarthritis Osteoarthritis, Knee Platelet Rich Plasma Rheumatic Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

CHU Amiens

Amiens, 80480, France

Location status: Recruiting

Location contact

Laure Le Monnier, MD

CONTACT

[email protected]

0322868258

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

age : > 18 years old
Patients benefiting, in the context of knee osteoarthritis, from viscosupplementation alone or from two injections of PRP, in combination with HA, at the Amiens University Hospital.

Exclusion criteria

Patient refusal to use the data
Language barrier
Age less than 18 years old.

Treatment and study plan

Primary outcomes

change of the visual analogue scale (VAS) from the "PRP + HA" group on the "HA alone" group

Time frame: up to one year

Study contacts

Contact information is provided by the study sponsor or research team.

LAURE LE MONNIER, MD

CONTACT

[email protected]

03 22 66 82 50

Sponsors and collaborators

Lead sponsor

Centre Hospitalier Universitaire, Amiens

Other

Registry information

Acronym: ISPAG

Important dates

Study start: 2021
Primary completion: 2026
Study completion: 2026
First posted: Sep 9, 2021
Registry last updated: Jun 15, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

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This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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