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OpenTrials
Completed

NCT Number: NCT07329062

Effect of Toothpastes on Oral Malodor

This study aimed to evaluate the effects of different toothpaste formulations on oral malodor in young adults, addressing the lack of clinical evidence regarding propolis- and probiotic-containing toothpastes, which have predominantly been investigated in mouthrinse, tablet, or chewing gum formulations.

Volunteers aged 18-30 years with baseline organoleptic assessment (OA) and Breath Checker® (BC) scores >0 were randomized into four toothpaste groups: propolis-containing (Glimo Beta), probiotic-containing (Glimo Pi), phosphate-based (Glimo Gamma), and a standard fluoride toothpaste (Sensodyne). Allocation concealment was ensured using identical coded containers, and outcome assessors were blinded. After exclusions, 52 participants completed the study. Oral malodor was evaluated at baseline (T0) and Day 14 (T1) using OA, BC measurements, and self-perceived oral malodor scores.

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Key information

Conditions

Oral Malodor (Halitosis) Halitosis Pathological Conditions, Signs and Symptoms Signs and Symptoms Signs and Symptoms, Digestive

Age range

18 year–30 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Cankiri Karatekin University

Çankırı, Merkez, Turkey (Türkiye)

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • • No systemic diseases or medications known to cause halitosis
  • No active periodontal disease requiring treatment
  • No antibiotic use within the previous month
  • No orthodontic or removable space-maintaining appliances
  • Non-smokers
  • Organoleptic score >0 and Breath-Checker® (BC) score >0 at baseline

Exclusion criteria

  • Participants reporting systemic conditions, active periodontal therapy, smoking, or antibiotic usage were excluded.

Treatment and study plan

Propolis Containing Toothpaste

Other

Participants were instructed to brush their teeth using propolis toothpaste twice daily (morning and evening) for 14 days as part of their routine oral hygiene.

Probiotic containing toothpaste

Other

Participants were instructed to brush their teeth using probiotic toothpaste twice daily (morning and evening) for 14 days as part of their routine oral hygiene.

Phosphate-based formulation toothpaste

Other

Participants were instructed to brush their teeth using Phosphate-based formulation toothpaste twice daily (morning and evening) for 14 days as part of their routine oral hygiene.

Standard fluoride toothpaste

Other

Participants were instructed to brush their teeth using standard fluoride toothpaste twice daily (morning and evening) for 14 days as part of their routine oral hygiene.

Primary outcomes

  1. Change in oral malodor severity

    Time frame: Baseline and Day 14

    Oral malodor was assessed using an organoleptic scoring method and a portable breath checker device. The change in scores from baseline to the end of the intervention period was evaluated.

Sponsors and collaborators

Lead sponsor

Çankırı Karatekin University

Other

Registry information

Official study title

Investigation of the Effect of Toothpastes With Different Ingredients on Oral Malodor in Young Adults

Important dates

Study start
2025
Primary completion
2025
Study completion
2025
First posted
Jan 9, 2026
Registry last updated
Jan 9, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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