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NCT Number: NCT02114281

Oral and Dental Health Status in Patients Suffering From Chronic Kidney Disease

A large panel of oral and dental diseases exist in patients suffering from chronic kidney disease (CKD) in end-stage renal disease: it concerns teeth, peridontium, alveolar bone and saliva and it has been already described in the literature. The consequences of oral diseases in systemic health are substantial, including increase of inflammatory parameters, alteration of nutrition and increase of cardiovascular risk factors. It has been shown before that several oral diseases can be considered as cardiovascular risk factor in the general population and in diabetic patients through the chronic inflammatory pathway. In CKD patients, the influence of oral diseases on the progression of the chronic kidney disease is not yet established, as most of the studies are focused on stage 5 CKD or dialysis patients. That's why the interactions between dental health and CKD will be evaluated in this population of patients, at different stages of the disease (stages 2 to 5).

The main objective will be to describe the oral diseases at each stage of CKD. Secondary objectives will be: (1) To evaluate the link between the oral health and the chronic kidney disease stage, the nutritional and inflammatory status; (2) Among patients needing dental treatments, to evaluate after 6 months and 12 months whether dental cares have an influence on nutrition parameters, inflammatory status and CKD; (3) to evaluate the completion of dental treatments after the dental consultation including advises on dental health.

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Key information

Conditions

Chronic Kidney Disease Chronic Disease Dental Caries Disease Attributes Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Halitosis Inflammation Kidney Diseases Male Urogenital Diseases Mouth Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Periodontal Diseases Periodontitis Renal Insufficiency Renal Insufficiency, Chronic Signs and Symptoms Signs and Symptoms, Digestive Stomatognathic Diseases Tooth Demineralization Tooth Diseases Urogenital Diseases Urologic Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Service de néphrologie, transplantation et dialyse - Hôpital Pellegrin

Bordeaux, 33076, France

About this study

The consequences of oral and dental diseases in general health are substantial, including acute infectious process starting from teeth or peridontium, benign or malignant diseases starting from mucosa or teeth/peridontium and an overall reduction of nutrition indices and a decrease of quality of life markers. More recently, an augmentation of systemic inflammatory reaction markers has been shown correlated with periodontal diseases, leading to an increase of cardiovascular diseases and/or diabetic risk in those patients. A large panel of oral and dental diseases has been described in patients suffering from chronic kidney disease (CKD) in a terminal stage or dialysis (haemodialysis and peritoneal dialysis). In CKD patients, the influence of oral diseases on the progression of the chronic kidney disease is not established today, as most of the studies are focused on stage 5 CKD or dialysis patients. That's why the interactions between dental health and CKD will be evaluated in these patients, at different stages of the disease (stages 2 to 5). In this study, it is hypothesized that the augmentation of inflammation and the alteration of nutrition due to oral diseases have an impact on the alteration of CKD patients, through the chronic inflammatory pathway. We will evaluate the oral and dental health at Day 0, 6 months and 12 months using several indices: the oral hygiene-simplified index, the community periodontal index in treatment needs index, the decayed missing filled per tooth index, the number of functional teeth index, the oral health impact profile index, the saliva composition, the evaluation of halitosis and a mucosa evaluation. In parallel, an evaluation of the influence of chronic oral diseases on nutrition, inflammation and progression of chronic kidney disease will be done: biological check-up, nutrition intake statement and body mass index.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • CKD patients, stage 2 to 5, under treatment in CHU de Bordeaux
  • Aged more than 18 years old
  • A free, informed and written consent will be established
  • Must have a medical plan
  • Patients have had no dental cares 6 months before the inclusion date

Exclusion criteria

  • Persons having a current law affair
  • Persons suffering from psychosis or severe mental impairment

Treatment and study plan

CARE

Other

Not care

Other

Primary outcomes

  1. Evolution of the status of oral health, which will be evaluated through several dental epidemiological indices (composite measure)

    Time frame: 12 months after the inclusion

    The primary outcome is a composite measure including :

    • Oral Hygiene Index-Simplified index (OHI-S)
    • Community Periodontal Index in Treatment Needs index (CPITN)
    • Decayed Missing Filled per Tooth Index (DMF-T)
    • Number of Functional Teeth index (FS-T)
    • Oral Health Impact Profile index (OHIP)
    • Saliva Check (stimulated and non stimulated saliva flow, pH, buffer activity)
    • Halitosis evaluation (quantification of sulfur volatils compounds)
    • Mucosa evaluation

Secondary outcomes

  1. Evolution of nutrition statement

    Time frame: 12 months after the inclusion

    food survey, biological assessment and body composition by bioelectrical impedance analysis

  2. Evolution of chronic inflammation

    Time frame: 12 months after the inclusion

  3. Progression of chronic kidney disease (CKD)

    Time frame: 12 months after the inclusion

  4. Compliance with dental treatments in CKD patients

    Time frame: 12 months after the inclusion

  5. Evolution of CKD diseases with/without dental treatments in those patients who need dental treatments

    Time frame: 12 months after the inclusion

Sponsors and collaborators

Lead sponsor

University Hospital, Bordeaux

Other

Registry information

Acronym: NEPHRODENT

Important dates

Study start
2014
Primary completion
2017
Study completion
2017
First posted
Apr 15, 2014
Registry last updated
May 14, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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