Effect of the Anticholinergic Drug Burden on Postoperative Delirium in Elderly Chinese Patients: A Nested Case-Control Study

This study aims to investigate the association between preoperative anticholinergic drugs burden and postoperative delirium in elderly Chinese patients.

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Key information

Conditions

Delirium - Postoperative Confusion Delirium Emergence Delirium Mental Disorders Nervous System Diseases Neurobehavioral Manifestations Neurocognitive Disorders Neurologic Manifestations Pathologic Processes Pathological Conditions, Signs and Symptoms Postoperative Complications Signs and Symptoms

Age range

65 year–90 year

Sex eligibility

All sexes

Study type

Observational

Primary location

First Medical Center of Chinese PLA General Hospital

Beijing, China

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

patients over 65 years; Undergoing general anesthesia; Inpatients who had surgery between Aprill 1, 2020 and Aprill 1, 2022.

Exclusion criteria

ASA grade V; preoperative Mini-Mental State Examination (MMSE) score <24;history of neurological disorders (such as cerebrovascular disease or dementia); emergency surgeries; operative duration ≤30 minutes, and cases with >5% missing data.

Treatment and study plan

Primary outcomes

postoperative delirium

Time frame: 7 days after surgery

Sponsors and collaborators

Lead sponsor

Hao Li

Other

Registry information

Acronym: ADB and POD

Important dates

Study start: 2020
Primary completion: 2022
Study completion: 2022
First posted: Apr 17, 2025
Registry last updated: Apr 17, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed