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NCT Number: NCT07684404

Effect of Systemic Vitamin D on Dental Implant Osseointegration

The primary goal for any oral implantologist is to obtain satisfactory healing and long-term treatment success. Osseointegration is the key to dental implant success8 and is required to achieve direct structural and functional connection between living bone and the surface of a load-bearing artificial implant, is critical for the long-term success of dental implants.

Successful dental implant therapy relies on achieving proper osseointegration, which ensures a stable structural and functional bond between the implant surface and surrounding bone. Although dental implants show a high overall success rate of around 95%.

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Key information

Conditions

Dental Implant Avitaminosis Deficiency Diseases Dental Implant Failed Malnutrition Nutrition Disorders Nutritional and Metabolic Diseases Vitamin D Deficiency

Age range

20 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

About this study

Implant success depends on several factors surgical and prosthetic factors (surgical technique and operator experience, timing and type of prosthetic loading and quality of pros-thetic rehabilitation), implant-related factors (material, design and surface), and patient-related factors (bone volume/quality at the recipient site and host response.

Despite the high success rate of dental implants, which is reported to be around 95%, failures due to lack of osseointegration remain a significant challenge Implant failures are classified according to the timing of the loss to Early Dental Implant Failure (EDIF) or late dental implant failure (LDIF). Early implant failure occurs due to improper implant placement and restoration, low bone volume or density, systemic conditions, or smoking.

Recent research has indicated that systemic health factors, particularly nutritional status, can significantly influence the process of osseointegration. Vitamin D is a major determinant of mineral homeostasis, promoting intestinal calcium and phosphorus absorption, which are required for optimal mineralization of bone.

Vitamin D also exerts direct actions on bone (probably by regulating the expression of several bone growth factors). It controls mineral metabolism and the bone homeostasis by increasing calcium availability, by regulating PTH secretion, and by direct effects on bone formation and resorption.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adults aged 20-60 with diagnosed vitamin D deficiency (<20 ng/mL).
  • Edentulous area in the posterior mandible or maxilla.
  • No history of previous dental implant failure, metabolic bone diseases, or conditions affecting bone healing.
  • Both genders are included

Exclusion criteria

  • Severe systemic diseases that could interfere with healing.
  • Patients already on vitamin D or calcium supplements.
  • Smokers or patients with poor oral hygiene practices.
  • Pregnant females

Treatment and study plan

Vit D

Drug

to address the relation between Vitamin D deficiency and Dental implant osseointegration for the identification of the participants whom may be non-responders to the vitamin D treatment

Other names: Dental Implant

Primary outcomes

  1. Treatment of Dental Implant Osseointegration

    Time frame: 3 Months

    Evaluation of the Primary implant stability measured immediately after implant placement using the Ostell device, which assesses resonance frequency analysis (RFA) values expressed as Implant Stability Quotient (ISQ). This measurement reflects the initial mechanical stability of the implant within the bone at the time of surgery.

  2. marginal bone loss after prosthesis placement

    Time frame: six months after proshtesis placement

    Marginal bone loss will be evaluated using cone beam computed tomography (CBCT) taken six months after prosthesis placement. The vertical distance between the implant shoulder and the first bone-to-implant contact will be measured on both mesial and distal aspects to assess the amount of peri-implant bone resorption over time.

Secondary outcomes

  1. Implant Survival Rate

    Time frame: six months after prosthesis placement

    Implant survival rate will be determined by the presence of the implant at the 6-month follow-up without any clinical or radiographic signs of failure, such as mobility, pain, infection, or significant bone loss. This outcome reflects the short-term success of the dental implant.

Study contacts

Contact information is provided by the study sponsor or research team.

Rana Mohamed Abu haiba, DSC

CONTACT

[email protected]

+201151306588

Sponsors and collaborators

Lead sponsor

Future University in Egypt

Other

Registry information

Official study title

Effect of Systemic Vitamin D on Dental Implant Osseointegration in Patients With Vitamin D Deficiency: A Randomized Controlled Clinical Study)

Acronym: VIDOS

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Jul 6, 2026
Registry last updated
Jul 6, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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