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NCT Number: NCT01328301

Effect of Speed-dependent Treadmill Training in Patients With Subacute Stroke

This study aimed to explore whether speed-dependent treadmill training is more effective at improving walking and balance performance than speed-stable treadmill training in patients with subacute stroke. Twenty-six patients with stroke completed 2 weeks of treadmill training. Results showed that speed-dependent treadmill training is more effective at improving walking speed and step length than speed-stable treadmill training in patients with subacute stroke.

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Key information

Conditions

Stroke Brain Diseases Cardiovascular Diseases Central Nervous System Diseases Cerebrovascular Disorders Hemiplegia Nervous System Diseases Neurologic Manifestations Paralysis Pathological Conditions, Signs and Symptoms Signs and Symptoms Vascular Diseases

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Margaret Mak

Hong Kong, China

About this study

Objectives: To compare the effects of speed-dependent treadmill training (SDT) on gait and balance performance in patients with sub-acute stroke. Design: Double-blinded randomized controlled trial. Subjects: Twenty-six patients with sub-acute stroke were randomly assigned to SDT (n=13) and control (n=13) groups. Methods: Subjects in the SDT group underwent short interval of walking trials with stepwise increases in the treadmill speed, following the principles of sprint training. Control subjects received gait training on the treadmill with a steady speed (SST). Gait speed, stride length, cadence, and Berg's balance score (BBS) were recorded and analysed before and after the 10 training sessions. Results: Results of two-way repeated measures ANOVA showed significant group x time interactions for gait speed and stride length (p < 0.05). Within each subject group, there were improvements in all gait parameters and BBS (all p < 0.001) after the training program. In addition, the SDT group showed significantly larger percentage increases in gait speed (by 72.8%) and stride length (by 29.2%) than the control subjects (p < 0.02). Conclusions: SDT in patients with sub-acute stroke resulted in larger gains in gait speed and stride length compared with SST. The positive findings provide evidence for clinical practice of SDT in enhancing gait function after stroke.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • first episode of stroke
  • within 1 month of stroke onset
  • hemiparesis resulting from unilateral ischemic stroke
  • Ashworth score of 0 or 1 indicating no spasticity or slight spasticity over the affected lower limb respectively
  • mini-mental status examination score of ≥ 23
  • the ability to walk on level ground without physical assistance and to walk on a treadmill with a minimum speed of 22.2 cm/s for 30s

Exclusion criteria

  • neurological diseases other than stroke,
  • active cardiovascular disease (i.e. American Heart Association class C or above),
  • lower limb fractures
  • total hip replacement
  • active rheumatoid arthritis that affected their gait performance
  • Patients who required assistance to ambulate before the stroke were also excluded

Treatment and study plan

Experimental

Other

For SDT training, subjects received short intervals of locomotion training with a treadmill. After walking for 30s, the subjects were given two minutes of rest. If they completed the first walking trial safely and without stumbling, the belt speed was increased by 10% on the next trial. However, if a subject failed to complete the first trial, the belt speed was decreased by 10% on the next trial. The speed of the treadmill was adjusted in each subsequent trial according to the same principle. Subjects usually completed 7-8 walking trials in one session. The belt speed was increased by a maximum of five increments within one training session.

Other names: Treadmill training with increasing speed

Speed-stable treadmill training

Other

Subjects in the control group walked on the treadmill with the belt speed adjusted according to their fastest over-ground gait speed. There was no adjustment of the belt speed throughout the 30-minute steady-speed treadmill training session.

Other names: Treadmill training with steady speed

Primary outcomes

  1. change in Walking speed

    Time frame: Change in walking speed from baseline to post-treatment, an expected average of 2 weeks

  2. change in stride length

    Time frame: Change in stride length from baseline to post-treatment, an expected average of 2 weeks

  3. change in cadence

    Time frame: Change in cadence from baseline to post-treatment, an expected average of 2 weeks

Secondary outcomes

  1. change in Berg's balance score

    Time frame: Change in Berg's balance score from baseline to post-treatment, an expected average of 2 weeks

Sponsors and collaborators

Lead sponsor

The Hong Kong Polytechnic University

Other

Collaborators

  • Tung Wah Hospital

Registry information

Official study title

Speed-dependent Treadmill Training is Effective to Improve Gait and Balance Performance in Patients With Sub-acute Stroke

Important dates

Study start
2008
Primary completion
2009
Study completion
2009
First posted
Apr 4, 2011
Registry last updated
Mar 20, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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