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Completed

NCT Number: NCT02583841

"Effect of Scaling and Root Planing on Liver Function Test (Alanine Aminotransferase and Aspartate Aminotransferase) in Systemically Healthy - Chronic Periodontitis Subjects: a Clinical Trial."

Aim:

To evaluate effect of non- surgical periodontal therapy on liver function in systemically healthy chronic periodontitis (CP) subjects.

Materials and methods:

The study is non surgical interventional trial, includes 50 CP subjects in the age group of 35- 60 years selected from the OPD (Out Patient Department) of department of periodontology Tatyasaheb Kore Dental College and Research center (TKDC and RC), Kolhapur. CP subjects were equally divided into test group and control group. Liver function test- aspartate aminotransferase (AST), alanine aminotransferase (ALT) were checked at baseline and at 1 month after treatment. Clinical examination includes plaque index, gingival index, sulcus bleeding index, probing depth, clinical attachment loss.

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Key information

Conditions

Chronic Periodontitis (CP) Subjects. Chronic Disease Chronic Periodontitis Disease Attributes Mouth Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Periodontal Diseases Periodontitis Stomatognathic Diseases

Age range

35 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Subjects with CP (moderate and severe) as per Centers for disease control and prevention (CDC) criteria 2007.
  • Patients without any known systemic diseases

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Exclusion criteria

  • Patients who have taken anti-inflammatory/antibiotic/antioxidant within 3 months of beginning of study.
  • Subjects who have undergone periodontal treatment within six months of inception of study.
  • Smokers, tobacco habits in any form and alcoholics.
  • Pregnant and lactating women.

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Treatment and study plan

Scaling and Root Planing

Procedure

scaling and root planing as an intervention was done in patients of the test group

Primary outcomes

  1. Alanine aminotransferase

    Time frame: 1month

  2. Aspartate aminotransferase

    Time frame: 1 month

Secondary outcomes

  1. plaque index

    Time frame: 1month

  2. gingival index

    Time frame: 1 month

  3. sulcus bleeding index

    Time frame: 1month

  4. probing depth

    Time frame: 1month

  5. Clinical attachment loss

    Time frame: 1 month

Sponsors and collaborators

Lead sponsor

Tatyasaheb Kore Dental College

Other

Registry information

Important dates

Study start
2015
Primary completion
2015
Study completion
2015
First posted
Oct 22, 2015
Registry last updated
Oct 22, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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