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Completed

NCT Number: NCT04260204

Effect of Retrograde Autologous Blood Priming on Pulmonary Mechanics in Pediatric Cardiac Surgery

The present study hypothesized that beyond its hemodynamic affects,retrograde autologus blood priming of cardiopulmonary bypass (RAP) has a positive impact on hemodynamics and pulmonary mechanics subjected to cardiac surgery.

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Key information

Conditions

Congenital Heart Disease Cardiovascular Abnormalities Cardiovascular Diseases Congenital Abnormalities Congenital, Hereditary, and Neonatal Diseases and Abnormalities Heart Defects, Congenital Heart Diseases

Age range

12 month–5 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

About this study

This prospective randomized study analyzed the clinical records of 124 children subjected to cardiac surgery for congenital heart diseases with left to right shunt. They comprised 64 patients with RAP and 60 patients conventional cardiopulmonary bypass priming. The preoperative, intraoperative and postoperative data of the studied patients were reported.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • children complained of congenital heart disease with left to right shunt pressure or volume load

Exclusion criteria

  • cyanotic heart disease

Treatment and study plan

Pediatric cardiac surgery

Procedure

Primary outcomes

  1. Comparison of postoperative peak air way pressure between the studied groups

    Time frame: 1 hour after surgery

    peak air way pressure (Paw) in cmH2O

  2. Comparison of postoperative air way resistance between the studied groups

    Time frame: 1 hour after surgery

    air way resistance (Raw) in cmH2O/L/sec.

  3. Comparison of postoperative Plateau pressure between the studied groups

    Time frame: 1 hour after surgery

    Plateau pressure in cm H2O

  4. Comparison of postoperative Lung compliance between the studied groups

    Time frame: 1 hour after surgery

    Lung compliance in L/cm H2O

  5. Comparison of postoperative Tidal volume between the studied groups

    Time frame: 1 hour after surgery

    Tidal volume in ml

Sponsors and collaborators

Lead sponsor

Ain Shams University

Other

Registry information

Official study title

Effect of Retrograde Autologous Blood Priming of Cardiopulmonary Bypass on Hemodynamic Parameters and Pulmonary Mechanics in Pediatric Cardiac Surgery

Acronym: RAPCPB

Important dates

Study start
2015
Primary completion
2019
Study completion
2020
First posted
Feb 7, 2020
Registry last updated
Mar 4, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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