Effect of Rectal Misoprostol in Reducing Intra-operative Blood Loss During Myomectomy

After getting approval from hospital's ethical committee, patients eligible for the study were recruited in the study according to the selection criteria. Before surgery, after taking informed written consent, patient's detailed history including demographics, parity & BMI was recorded. Uterine size was assessed by bimanual pelvic examination. Patients undergoing myomectomy were randomly divided into 2 groups using lottery method. In experimental group Misoprostol 400ug was administered per rectally prior to surgery. In control group, no drug was administered.

The surgical procedural elements, the surgeon or surgeons performing the procedure and the use of antibiotics as well as anesthetic agents was standardized to remove any bias. Intraoperative blood loss was recorded by a single trained doctor and calculated using visual scale for the abdominal sponges and chest swabs/gauzes used during surgery and blood collected in suction bottle.

Inclusion criteria

• ASA physical status class I-II
• Intramural or subserosal fibroids - diagnosed on ultrasound
• Candidates for elective abdominal myomectomy

Exclusion criteria

• Pre-operative Hemoglobin < 10 g/dl
• Patient who received Danazol or GnRH analogues before surgery
• No other systemic or metabolic disease