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NCT Number: NCT07303530

Effect of Printing Layer Thickness on Growth of Candida Albicans in Completely Edentulous Patients Rehabilitated With 3D-Printed Maxillary Complete Denture Bases.

In completely edentulous patients rehabilitated with 3D-printed maxillary dentures bases, does the printing layer thickness affect candidal adherence and growth on the fitting surface of dentures.

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Key information

Conditions

Printed Dentures Torulopsis

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

cairo University hospital, Cairo, Cairo Governorate, Egypt

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About this study

The trial will follow a cross-over design, where each participant will wear denture bases printed with three different layer thicknesses (25 µm, 50 µm, and 100 µm) at a random order. Each participant will wear each of the three dentures for an 8-week period, with a washout period of two weeks between each thickness.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Completely edentulous patients aged 30-80 years
  • Oral cavity is free from any mucosal lesions.
  • No systemic conditions that would contraindicate participation in the study.

Exclusion criteria

  • History of allergic reactions to denture materials.
  • Active mucosal lesions related to denture use.
  • Pregnancy or lactation.

Treatment and study plan

printing layer thickness of denture

Device

denture printed by multiple printing layer thicknesses to assess effect of layer thickness on fungal growth

Other names: other printing layer thickness

Primary outcomes

  1. Candidal growth

    Time frame: 8-10 weeks

    candidal growth over denture surface measured by colony-forming units (CFU)

Sponsors and collaborators

Lead sponsor

Cairo University

Other

Registry information

Official study title

Effect of Printing Layer Thickness on Growth of Candida Albicans in Completely Edentulous Patients Rehabilitated With 3D-Printed Maxillary Complete Denture Bases: A Randomized Cross-over Study

Important dates

Study start
2026
Primary completion
2026
Study completion
2027
First posted
Dec 26, 2025
Registry last updated
Dec 26, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

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This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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