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NCT Number: NCT07574827

Candida Albicans in Syrian Patients With Periodontitis

Periodontitis is a significant oral health issue characterized by inflammation and destruction of the supporting structures of the teeth. Recent research has indicated that Candida albicans, a common fungal pathogen, may play a role in the exacerbation of periodontal diseases. This study aims to investigate the prevalence and impact of Candida albicans in Syrian patients diagnosed with periodontitis, contributing to a better understanding of its role in oral health within this population.

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Key information

Conditions

Periodontal Disease Mouth Diseases Periodontal Diseases Periodontitis Stomatognathic Diseases Torulopsis

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Al-Hawash Private University, Faculty of Dentistry

Homs, Syria

Location status: Recruiting

Location contact

Ali Abou Sulaiman, PhD

CONTACT

[email protected]

+963956790836

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients aged 18 years and older.
  • Diagnosed with chronic periodontitis based on clinical examination (attachment loss, probing depth).
  • Consent to participate in the study.

Exclusion criteria

  • Patients with systemic diseases affecting oral health (e.g., diabetes, immunosuppressive conditions).
  • Recent antibiotic or antifungal treatment within the last three months.

Treatment and study plan

Periodontal Assessment and Sample Collection from Subgingival Pockets

Diagnostic Test

Clinical examination to assess periodontal status. Collection of subgingival plaque samples for microbiological analysis to identify Candida Albicans.

Primary outcomes

  1. Detection of Candida Species in Subgingival Samples

    Time frame: At enrollment

Secondary outcomes

  1. Periodontal Screening and Recording Index

    Time frame: At enrollment

    Periodontal parameters are measured using the WHO probe by dividing the mouth into six sextants (three upper, three lower). The highest score in each sextant is recorded. Scoring from 0-4 is based on pocket depth, gingival health, and calculus presence.

    Scoring Criteria:

    0: Healthy periodontium, black band visible.

    • Bleeding on probing (BOP), black band visible.
    • Calculus present, black band visible.
    • Pocket depth 3.5-5.5 mm (black band partially submerged).
    • Pocket depth > 5.5 mm (black band entirely hidden).

Study contacts

Contact information is provided by the study sponsor or research team.

Ali Abou Sulaiman

CONTACT

[email protected]

+963956790836

Sponsors and collaborators

Lead sponsor

Al-Hawash Private University

Other

Registry information

Official study title

Prevalence and Impact of Candida Albicans in Syrian Patients With Periodontitis: A Cross-Sectional Study

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
May 8, 2026
Registry last updated
May 8, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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