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Completed

NCT Number: NCT02708537

Effect of Plasma Rich in Growth Factors on Semen Quality

The hypothesis is growing semen samples with plasma rich in growth factors (PRGF), because it could improve sperm motility in patients subsidiary TRA, ultimately improving pregnancy rates.

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Key information

Conditions

Vascular Endothelial Growth Factor Overexpression

Age range

18 year–35 year

Sex eligibility

Male

Study type

Observational

Primary location

IVI Bilbao, Leioa, Vizcaya, Spain

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About this study

Platelet growth factors are a group of proteins involved in cellular communication modifying biological responses. Obtaining plasma rich in growth factors is already widespread and simple protocol technique that is being used in various areas of medicine with superb results. Described many of the growth factors present in the PRGF are related to sperm parameters, especially motility The described effects have been studied in mammalian and each growth factor individually. PRGF contains a pool of growth factors and therefore be interesting to analyze their effect on various sperm parameters.

One of those parameters is very important for fertilization sperm motility, since the lack of it will prevent displacement by the cervix to meet the egg in the fallopian tube.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • 18-35 years
  • more than 5 million sperm per milliliter

Exclusion criteria

  • Not having genetic and infectious diseases
  • Do not suffer mental illness
  • Have a family study determined that there is no risk of hereditary diseases
  • There have fathered more than 6 children in the country

Treatment and study plan

PRGF in candidates for sperm donors

Biological

PRGF application on seminal aliquots will be conducted at different concentrations assessing sperm motility.

Primary outcomes

  1. Evaluate the percentage of motile sperm adding PRGF versus those samples that growth factors were not added

    Time frame: 6 months

    Within concerted donor visits in IVI Bilbao will be held:

    • Removing Blood 9 mL of blood to obtain plasma rich in factors growth
    • Seminogram to analyze all semen parameters according to the criteria of the WHO (2010), paying particular attention to sperm motility.
    • Sperm vitality will be analyzed before and after treatment with PRGF. PRGF application on the seminal aliquots will be conducted at different concentrations assessing sperm motility.

Sponsors and collaborators

Lead sponsor

IVI Bilbao

Other

Collaborators

  • bTI Vitoria

Registry information

Official study title

Effect of Plasma Rich in Growth Factors (PRGF) on Semen Quality

Important dates

Study start
2016
Primary completion
2016
Study completion
2017
First posted
Mar 15, 2016
Registry last updated
Aug 1, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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