Effect of Physical Training on Oxygen Uptake and Endothelial Function in Heart Transplant Recipients

The purpose of this study is to investigate the effect of physical training on work capacity and vascular function after heart transplantation, cardiac transplant recipients are randomized to 8 weeks of intense physical training or control. Vascular function is measured non-invasively. Effect on the hormones and the immune system is evaluated using blood samples.

Completed

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Key information

Conditions

Heart Transplantation Endothelial Function Exercise Capacity

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

About this study

To investigate the effect of physical training on work capacity and vascular function after heart transplantation, cardiac transplant recipients are randomized to 8 weeks of intense physical training or control. Vascular function is measured non-invasively using forearm flow mediated dilatation. Effect on the blood natriuretic peptides and the inflammatory markers is evaluated using blood samples at baseline and after the training or control period.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Heart transplant recipients > 1 year after transplantation

Exclusion criteria

Recent rejection, severe renal dysfunction, graft dysfunction, allograft vasculopathy, cancer, inability to exercise.

Treatment and study plan

Intensive physical exercise

Other

Intensive physical exercise 1 hour three times per week

Primary outcomes

Change in maximal oxygen uptake.

Time frame: 8 weeks

Secondary outcomes

Change inm flow mediated vasodilatation.

Time frame: 8 weeks

Sponsors and collaborators

Lead sponsor

Rigshospitalet, Denmark

Other

Registry information

Important dates

Study start: 2009
Primary completion: 2009
Study completion: 2010
First posted: Dec 9, 2009
Registry last updated: Oct 28, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed