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Completed

NCT Number: NCT00213915

L-arginine Supplementation and Exercise; L-arginine Supplementation and Renal Function

* exercise capacities are still altered after heart transplantation partly due to peripheral endothelial dysfunction * cyclosporin-induced renal dysfunction may be due to renal endothelial dysfunction and can be reversed in an animal model by L-arginine supplementation * to determine the potential beneficial effect of L-arginine supplementation on exercise capacity and renal function of heart transplant recipients

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Key information

Conditions

Heart Transplantation

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

Institut de Physiologie, Strasbourg, France

Loading trial locations.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Male (> 18 years old) stable heart transplant recipient for at least 6 weeks
  • Stable treatment for at least 3 months
  • Sedentary people

Exclusion criteria

  • Unstable cardiac pathology
  • Obesity (IMC > 40)
  • Participation in another study in the last month
  • Chronic renal failure (creatinine clearance < 20 ml/min)
  • Renal transplantation
  • Diabetes
  • Impossibility to practice exercise test
  • Nitrate therapy

Treatment and study plan

12 g of L-arginine glutamate during 6 weeks twice a day

Drug

Primary outcomes

  1. Maximal and sub maximal exercise capacity at the end of the 6 weeks L-arginine supplementation. Renal function at the end of the 6 weeks

Secondary outcomes

  1. No secondary effects

Sponsors and collaborators

Lead sponsor

University Hospital, Strasbourg, France

Other

Registry information

Official study title

Effects of Oral Chronic L-arginine Supplementation on Exercise and Renal Function of Heart Transplant Recipients

Important dates

Study start
2004
Study completion
2004
First posted
Sep 21, 2005
Registry last updated
Dec 22, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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