Non-surgical periodontal treatment
ProcedureRemoval of deposits above and below the gum line using hand or ultrasonic tools and thorough smoothing of root surfaces to discourage re-accumulation of bacteria.
NCT Number: NCT07070453
Photodynamic therapy (PDT) is an innovative technique that utilizes light-activated agents, known as photosensitizers, to produce reactive oxygen species capable of targeting and eliminating pathogens. This therapeutic approach has been explored in a variety of medical fields due to its versatility and minimal invasiveness. In the context of periodontal diseases, PDT has emerged as a promising adjunctive treatment in the non-surgical management of periodontitis. Periodontitis, a chronic inflammatory disease caused by the accumulation of pathogenic bacteria in the subgingival environment, is often treated with mechanical debridement, including scaling and root planing (SRP). However, these conventional methods may not always achieve complete bacterial eradication. PDT, when used in conjunction with SRP, has the potential to significantly enhance bacterial elimination. The use of photosensitizers, activated by specific wavelengths of light, leads to the generation of singlet oxygen, which can effectively kill a broad spectrum of periodontal pathogens, including those resistant to antibiotics. As an adjunctive therapy, PDT can improve the clinical outcomes of non-surgical periodontitis treatment by reducing bacterial load, promoting tissue healing, and potentially decreasing the need for more invasive procedures. The ability of PDT to target bacteria without harming surrounding tissues makes it an attractive option for patients who require a non-invasive treatment approach. In conclusion, photodynamic therapy is a valuable addition to periodontal treatment regimens, offering enhanced bacterial reduction and improved therapeutic outcomes in the management of periodontitis.
Interested in participating?
Request Info18 year and older
All sexes
Interventional
Not applicable
Egas Moniz School of Health and Science, Almada, Monte Da Caparica, Portugal
Healthy volunteers accepted: No
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
Exclusion criteria
Removal of deposits above and below the gum line using hand or ultrasonic tools and thorough smoothing of root surfaces to discourage re-accumulation of bacteria.
Non-invasive treatment that uses a combination of a light-sensitive compound (photosensitizer), specific light, and oxygen to generate reactive oxygen species (ROS) that kill bacteria.
Time frame: From enrollment to the end of treatment at 3 months.
Changes in the microbiome collected from periodontal pockets sequencing 16S ribosomal RNA gene
Time frame: From enrollment to the end of treatment at 3 months.
Probing depth, measuring in millimeters the distance from the gingival margin to the base of a sulcus or periodontal pocket, using a periodontal probe.
Contact information is provided by the study sponsor or research team.
Filipa Sousa, Master
CONTACT
Inês Dra. Gomes, phd
CONTACT
Egas Moniz - Cooperativa de Ensino Superior, CRL
Other
Acronym: PerioFPS
OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.
View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.
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