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NCT Number: NCT07739732

Periodontitis on Gingival Crevicular Fluid Metobolomics

This cross-sectional observational study will compare the gingival crevicular fluid metabolomic profile of 30 adults with periodontitis and 30 periodontally healthy adults. Participants will undergo a periodontal examination and gingival crevicular fluid collection during a single study visit. Targeted metabolomic analysis will be used to identify differences between the two groups and associations with periodontal clinical parameters.

Recruiting

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Key information

Conditions

Periodontitis Mouth Diseases Periodontal Diseases Stomatognathic Diseases

Age range

18 year–70 year

Sex eligibility

All sexes

Study type

Observational

Primary location

About this study

Sixty adults will be enrolled: 30 with periodontitis and 30 with periodontal health. Gingival crevicular fluid will be collected using four sterile absorbent paper strips inserted sequentially into the deepest eligible periodontal site or gingival sulcus. The strips will be pooled in a coded tube and stored immediately at -20 °C. Blood-contaminated samples will be discarded. Laboratory personnel will be blinded to group allocation. Targeted metabolomic findings will be compared between groups and correlated with periodontal clinical parameters.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age between 18 and 70 years.
  • Ability to understand the study procedures and provide written informed consent.
  • For the periodontitis group: diagnosis of periodontitis according to the 2018 classification of periodontal diseases.
  • For the healthy control group: periodontal health according to the 2018 classification, with no current diagnosis or history of periodontitis.

Exclusion criteria

  • Periodontal treatment during the previous 6 months.
  • Use of antibiotics, non-steroidal anti-inflammatory drugs, or immunosuppressive agents during the previous 6 months.
  • Pregnancy.

Treatment and study plan

Periodontal probing depth

Other

Periodontal probing depth measured in millimeters

Primary outcomes

  1. Probing pocket depth

    Time frame: Baseline

Study contacts

Contact information is provided by the study sponsor or research team.

Gaetano Isola

CONTACT

[email protected]

0953785652

Sponsors and collaborators

Lead sponsor

University of Catania

Other

Registry information

Official study title

Impact of Periodontitis on Metabolomics in Gingival Crevicular Fluid

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Jul 31, 2026
Registry last updated
Jul 31, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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