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OpenTrials
Completed

NCT Number: NCT00923988

Effect of Passive Smoking on Platelet Function and Endothelial Function

Passive smoking is associated with an increased risk for cardiovascular events. However, the exact mechanisms by which passive smoking affects cardiovascular health are not entirely understood. In the present study, the researchers investigate the effects of short-term exposure to secondhand smoke on platelet function and peripheral microvascular endothelial function in healthy individuals. For this purpose, platelet function and endothelial function are measured before and after a 1-hour exposure to secondhand smoke in a concentration that is encountered in bars and restaurants without smoke-free policies. The researchers' hypothesis is that short-term exposure leads to platelet activation and impairment of endothelial function.

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Key information

Conditions

Endothelial Function Platelet Aggregation

Age range

18 year–50 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Kantonsspital Graubuenden

Chur, 7000, Switzerland

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • healthy individuals
  • nonsmokers
  • no regular medication (in particular no drugs affecting platelet function or vascular function)

Exclusion criteria

  • exposition to secondhand smoke within 1 week before inclusion
  • use of drugs affecting platelet function or vascular function within 1 week before study inclusion

Treatment and study plan

secondhand smoke exposure

Other

Participants will be exposed to secondhand smoke for one hour. As a measure of secondhand smoke exposition, room carbon monoxide concentration will be continuously measured using an Ambient Carbon Monoxide Monitor APMA-360 and kept constant between 4.5-6.0 ppm. Levels in this magnitude are typically seen in smoking areas of restaurants and bars.

Primary outcomes

  1. Change in platelet aggregation and/or endothelial function

    Time frame: 12-24 hours

Sponsors and collaborators

Lead sponsor

Kantonsspital Graubünden

Other

Registry information

Official study title

Acute Effects of Short-term Exposure to Secondhand Smoke on Platelet Activation and Endothelial Function

Important dates

Study start
2009
Primary completion
2009
Study completion
2009
First posted
Jun 18, 2009
Registry last updated
Aug 11, 2009

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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