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Completed

NCT Number: NCT00733161

Effect of Passive Exercise on Systemic Endothelial Function in Elderly Patients With Chronic Heart Failure

The purpose of this study is to determine the effect of passive exercise on systemic endothelial function in elderly patients with chronic heart failure.

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Key information

Age range

65 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine

Kyoto, 606-8507, Japan

About this study

Endothelial function is known to be impaired in patients with chronic heart failure (CHF) and impaired endothelial function has been reported to be associated with an increased mortality risk in those subjects. Although systemic exercise training has been demonstrated to improve endothelial dysfunction in patients with CHF, elderly patients with severely impaired exercise capacity could not engaged in usual exercise training using ordinal ergometer. Those patients are able to join stretching or very light resistance training. On the other hand, passive pedaling using strength ergometer has been reported to be useful in patients with severely impaired exercise capacity, but the safety and the efficacy of passive pedaling on endothelial function in old patients with CHF has not been previously reported.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Clinical diagnosis of chronic heart failure
  • Elderly patients aged ≧65 years
  • Patients with severely reduced exercise capacity and cannot continue exercise with usual cycling ergometer for 5 minutes

Exclusion criteria

  • Unstable hemodynamic status (uncontrolled arrhythmia, uncontrolled congestion, uncontrolled hypertension)
  • Active infectious disease
  • Malignancy
  • Chronic obstructive pulmonary disease
  • Dialysis
  • Severe aortic valve disease
  • With any hip, knee, ankle joint pain
  • Hemiplegia
  • Current smoker

Treatment and study plan

Passive leg cycle exercise with stretching and resistance training

Other

Passive leg cycle exercise for 15 minutes everyday as well as stretching and resistance training

Stretching and resistance training

Other

Stretching and resistance training everyday but no Passive leg cycle exercise

Primary outcomes

  1. Endothelial function

    Time frame: 2 weeks

Secondary outcomes

  1. Left ventricular systolic and diastolic function

    Time frame: 2 weeks

  2. Six-minute walk distance

    Time frame: 2 weeks

Sponsors and collaborators

Lead sponsor

Kyoto University

Other

Registry information

Important dates

Study start
2008
Primary completion
2010
Study completion
2010
First posted
Aug 12, 2008
Registry last updated
Oct 4, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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